6-2. The Integumentary System. Functions of the skin and subcutaneous tissueepidermis and dermishypodermisthick and thin skinskin colorskin markingsHair and nailsCutaneous glandsSkin disorders. 6-3. Overview. Largest organ (15% of body weight)Epidermiskeratinized stratified squamous epitheliumDermisconnective tissue layerHypodermisThickness variable, normally 1-2 mmdermis may thicken, up to 6 mmstratum corneum layer increasedcalluses on hands and feet.