lexine
Uploaded by
25 SLIDES
340 VIEWS
250LIKES

GABA Mediated Responses in Rat Carotid Body Neurons Co-Cultures

DESCRIPTION

Investigating GABA expression and actions in rat carotid body neurons, exploring postsynaptic effects via GABAa receptors and presynaptic effects via GABAb receptors. Discover the autoregulatory feedback mechanism involving TASK-1 channels in fast synaptic transmission.

1 / 25

Download Presentation

GABA Mediated Responses in Rat Carotid Body Neurons Co-Cultures

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. GABA Mediates Responses in Co-cultures of Rat Carotid Body and Petrosal NeuronsMin ZhangDepartment of Biology, McMaster University, Hamilton, Ontario, Canada

  2. type 1 PN

  3. Postsynaptic action of BABA via GABAa receptors

  4. Presynaptic action of GABA via GABAbrecepors

  5. Summary • GABA is expressed in carotid body chemoreceptor type 1 cells. • GABA released from the CB during hypoxia, inhibits sensory discharge postsynaptically via a shunting mechanism involving GABAa receptors. • GABAb receptor-mediated activation of TASK-1 or related channel provides a presynapticautoregulatory feedback mechanism that modulates fast synaptic transmission in rat carotid body.

More Related