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GABA Mediated Responses in Rat Carotid Body Neurons Co-Cultures

Investigating GABA expression and actions in rat carotid body neurons, exploring postsynaptic effects via GABAa receptors and presynaptic effects via GABAb receptors. Discover the autoregulatory feedback mechanism involving TASK-1 channels in fast synaptic transmission.

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GABA Mediated Responses in Rat Carotid Body Neurons Co-Cultures

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  1. GABA Mediates Responses in Co-cultures of Rat Carotid Body and Petrosal NeuronsMin ZhangDepartment of Biology, McMaster University, Hamilton, Ontario, Canada

  2. type 1 PN

  3. Postsynaptic action of BABA via GABAa receptors

  4. Presynaptic action of GABA via GABAbrecepors

  5. Summary • GABA is expressed in carotid body chemoreceptor type 1 cells. • GABA released from the CB during hypoxia, inhibits sensory discharge postsynaptically via a shunting mechanism involving GABAa receptors. • GABAb receptor-mediated activation of TASK-1 or related channel provides a presynapticautoregulatory feedback mechanism that modulates fast synaptic transmission in rat carotid body.

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