An Examination of Penicillin Allergy. Resident Grand Rounds February 12, 2002 David H. Priest, MD. Outline. Introduction What is a true penicillin allergy? How can we determine who is truly allergic?
Resident Grand Rounds
February 12, 2002
David H. Priest, MD
- Usually occur within 1 hour of admin. - Consist of any combination of diffuse erythema, pruritus, urticaria, angioedema, bronchospasm, laryngeal edema, hyperperistalsis, hypotension and cardiac arrhythmias.
- 0.004%-0.015% of tx courses - Most often in adults 20-49 years. - More common if hx of atopy or parenteral admin - Fatal outcomes in 1 per 50,000-100,000 admin.
- Skin testing does have a role in evaluation of these pts.