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FARMASEUTIK

FARMASEUTIK. FARMAKO KINETIK. KONSTAN. TRANSELULAR 2.5 %. EKSTRA SELULAR 22 %. INTRA SELULAR 30 – 40 %. C S S. PLASMA 4.5 %. INTERSTISIAL 16 %. LIMFE 1-2 %. INTRAOKULER. PERITONEAL. PLEURA. BIOTRANSFORMASI OBAT PERUBAHAN STRUKTUR KIMIA METABOLISME - HATI (UTAMA)

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FARMASEUTIK

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  1. FARMASEUTIK FARMAKO KINETIK

  2. KONSTAN TRANSELULAR 2.5 % EKSTRA SELULAR 22 % INTRA SELULAR 30 – 40 % C S S PLASMA 4.5 % INTERSTISIAL 16 % LIMFE 1-2 % INTRAOKULER PERITONEAL PLEURA

  3. BIOTRANSFORMASI OBAT PERUBAHAN STRUKTUR KIMIA METABOLISME - HATI (UTAMA) - TGI - PLASMA - PARU OBAT - TIDAK AKTIF (UMUM), TIDAK TOKSIK - AKTIF (PRODRUG) - TOKSIK REAKSI METABOLISME • Rx FASE I : OKSIDASI, REDUKSI, HIDROLISA KADANG BISA LEBIH AKTIF • Rx FASE II : KONYUGASI (TIDAK AKTIF) OBAT FASE I DERIVAT OBAT FASE II KONYUGAT • OKSIDASI KONYUGASI • HIDROKSILASI • DEAKILASI • DEAMINASI FENASETIN PARASETAMOL PARASETAMOL KONYUGAT METABOLIT LARUT BAIK DALAM AIR

  4. K1 K2

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