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ADME WorkBench Status, Plans, Current Applications (What’s New?). September 17, 2013 Conrad Housand chousand@aegistg.com support@admewb.com , www.admewb.com. Agenda. Introduction We intend for this to become a monthly user’s group meeting (but non-users are welcome to attend)

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adme workbench status plans current applications what s new

ADME WorkBenchStatus, Plans, Current Applications(What’s New?)

September 17, 2013

Conrad Housand

chousand@aegistg.com

support@admewb.com, www.admewb.com

agenda
Agenda
  • Introduction
    • We intend for this to become a monthly user’s group meeting (but non-users are welcome to attend)
    • We’ll review newly added features from the previous month
    • We’ll describe the status of features currently in development, and their estimated availability date
    • We’ll talk about upcoming events
    • We’ll present user research and applications
    • We’ll listen to feedback from customers and the ADME community
new features
New Features
  • Gut metabolism
    • Scale from intestinal microsomes (linear/saturable)
    • Scale from liver microsomes (linear/saturable)
  • Gut transporters
    • Influx/efflux based in total microsomal abundance (linear/saturable)
    • Influx/efflux based on microsomal abundance relative to illeum/Caco2 (linear/saturable)
new features1
New Features
  • Saturable renal clearance
    • Tubular secretion/reabsorption
  • Externally-defined absorption rate
    • Imported tabular absorption rate vs. time data
  • User-defined model parameters
    • Additions to user interface and project database
    • Provides “hook” to custom code in PBPK model
in development
In Development
  • Additional target species
    • Rabbit, monkey, guinea pig
  • User-defined PBPK tissues
    • User-specified physiological parameters
  • Variability
    • Basic physiological parameters
  • Age dependence
    • Basic physiological parameters, some metabolism
in development1
In Development
  • Advanced inhalation model
    • Gloede + additions for particulate deposition and dissolution
  • Metabolites
    • Parallel PBPK models to track parents/metabolites
    • Metabolism in multiple tissues: gut, liver to start
in development2
In Development
  • Examples
    • Midazolam w/ transporters
  • Dermal absorption
    • Externally-supplied flux
    • Thanks to John Troutman, P&G
in development3
In Development
  • Next webinar in October
    • http://www.admewb.com/webinars/
    • http://www.admewb.com/webinars/
    • October 22: http://bit.ly/16biFZf
    • October 24: http://bit.ly/1f08Ghq
thank you
Thank you

Questions?

Thank you!