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Technology Transfer at the University of Colorado Health Sciences Center

Technology Transfer at the University of Colorado Health Sciences Center. Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions. Vivian Dullien, PhD Director Vivian.dullien@uchsc.edu. Rick Silva, PhD Licensing Associate Rick.silva@uchsc.edu.

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Technology Transfer at the University of Colorado Health Sciences Center

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  1. Technology Transfer at the University of ColoradoHealth Sciences Center Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions Vivian Dullien, PhD Director Vivian.dullien@uchsc.edu Rick Silva, PhD Licensing Associate Rick.silva@uchsc.edu Jennifer Eby, MS, MBA Licensing Associate Jennifer.eby@uchsc.edu Jill Jones Contract Administrator Jill.jones@uchsc.edu

  2. Our Mission Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions …aggressively pursue, protect, package, and license to business the intellectual property generated from the research enterprise and to serve faculty, staff, and students seeking to create such intellectual property.

  3. Our stakeholders Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions The University Faculty VPAAR, President, and Regents Students The Community Our partners Industries we partner with The business community at large

  4. Functions Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions Faculty Service Commercial partnerships and contracts Revenue Center for the University Licensing royalties and research revenues Augment Impact of Research Mission Commercial development of tangible/intellectual output Economic Development Startups and jobs

  5. Guiding Principles Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions Faculty involvement in the commercialization process Create long-term value through commercial investment and technology adoption Transactions reflect upside for the University Recover patent costs and reinvest in our faculty Adopt and implement “best practices” for licensing Empowerment of a skilled and experienced professional staff Responsiveness to industry needs and requests

  6. Service capabilities Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions For Faculty… Management of intellectual resources Foster industry partnerships License and commercialize technology Educational programs in concert with business community Assistance in networking, raising capital, establishing management

  7. Service capabilities Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions • Facilitate collaborations from an industry friendly perspective • Access to our pipeline • Finding synergy • Defining and creating opportunities • Market research, diligence, and business plans in University startups • Management of conflicts-of interest, contracts, and other aspects of University-commercial relationships For the business community…

  8. Benchmarks Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions $300 M in federal funding in FY 2000 CU ranks #4 among all public institutions and #8 among all institutions in federal R&D funding CU Health Sciences Center ranked 5th among all public U.S. medical schools in NIH funding per faculty member By most accounts CU has been under- performing in technology licensing

  9. Our context Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions • The Front Range is an entrepreneurial technology centric, destination community. • Fitzsimmons BioPark is a lifetime opportunity. • The technology licensing operation changed organizational structure four times in last 12 years. • Administration is committed to high performance operation – moving from 8 to 15 employees. • President Hoffman is committed to a University Without Walls as part of her vision for 2010.

  10. Hard Metrics Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions Disclosure rates Patents issued Companies started Products launched Revenues generated

  11. Hard Metrics Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions

  12. Target Metrics Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions GROWTH Disclosures Patents Startups Revenues

  13. Soft Metrics Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions Sound portfolio Inventor sophistication Entrepreneurial potential Business relationships Jobs creation Economic impact Societal impact

  14. Our challenges Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions Balancing the academic mission with the commercial objective Meeting our peer benchmarks Engendering the trust and participation of our faculty Adapting to swift and brutal changes in market forces and the business environment Bridging the “gap” …Our history is not our destiny

  15. Technology Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions The ideal… The inventor has thought about a problem in the context of product development for a lucrative market Proof of concept work is done Infrastructure in place to exploit technology The commercial partner in is the queue …the blockbuster drug or the killer app

  16. Technology Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions The reality… Raw technologies Not directed to a market problem Product has not been defined or conceived Data directed at curiosity, publication, and next grant cycle Lack of infrastructure for revolutionary advances …a solution looking for a problem

  17. Technology- the “gap” Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions The risk gap- this is not venture capital SBIR/STTR CAPCO RAID and RAPID programs at NIH Some universities have gap funds

  18. Licensing Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions Product IP Typically exclusive, rarely a startup Platform IP Startup or existing company, sometimes divided uses Process IP Often nonexclusive to existing companies

  19. Licensing Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions Therapeutic compositions Typically exclusive, valuable but rare Drug delivery and formulation Startup or existing company, sometimes divided uses, often freedom to operate and other strategic issues Drug discovery and development Often nonexclusive to existing companies, rarely end up in a product Reagents Distribution licenses, rarely patented unless they have a product or proprietary gate element

  20. Licensing Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions Biomarkers and diagnostics Typically nonexclusive, most don’t have regulatory and clinical lab infrastructure in place Software Bioinformatics tools, usually code modules requiring interface, platform and recoding

  21. Start Ups Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions Ingredients for Success: Professional management Adequate capitalization Market scope Involved inventor- marquee name Technology- Platform or process IP Experienced, serial management, board, inventors, and investors

  22. Start UpsLiquidity events Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions Amgen* (Kineret 2002 sales of $70 million, cofounded by CU researcher Dr. Marv Carruthers) Ribozyme (UCB; over $100 million, now Sirna; a Nobel prize) NexStar/Biostar (UCB; $550 million purchase by Gilead) Eyetech ($124 million) Myogen ($70 million IPO + 90 Million private; $350 million cap) Dharmacon ($80 million, private purchase) …over $1 Billion in equity capital raised with CU life sciences technology in a decade

  23. Start UpsVenture funded companies Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions Replidyne ($13 million) Globeimmune ($8 million) SomaLogic (UCB; $19.5 million) RxKinetix (>$3 million) Acceleration bioPharmaceuticals

  24. Start UpsOn the radar screen… Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions Newellink (Immunolgy and metabolism) Lohocla (Psychiatry biomarkers) ARCA discovery (Cardiac drugs) Sentry Biosciences (Cancer, apoptosis) Trasona (IV drugs for trauma and stress) Taligen (Complement mediated diseases) Barofold (Protein therapeutic processing) Activedry (Drug formulation and delivery)

  25. Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions Licensing and foundational roles Dr. Marv Carruthers DNA synthesis technologies Kineret- Dr. William Arend Clinical development and license collaborations

  26. Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions A model case: An entrepreneurial faculty group True synergies leveraging University assets on the cutting edge Strong inventors An evolving partnership

  27. NeXstar Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions SELEX* aptamer technology- implications in: Drug discovery (Gilead and Eyetech) Biosensors Diagnostics (Somalogic) Chromatography *Systematic Evolution of Ligands of Exponential enrichment

  28. Summary Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions Our current system portfolio: Patents Issued 240 Patents in Prosecution: 151 Active Licenses/Options: 155 Viable Start-ups: 27

  29. Questions? Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions

  30. TTO Business Advisory Board Sandy Bracken, Director, Bard Center for Entrepreneurship, CU Denver Chad Brownstein, Partner, ITU Ventures Michael Byram, President, University of Colorado Foundation Greg Carlisle, Partner, Gefinor Ventures Maggie Cary, Chief Medical Officer, Colorado Business Group on Health Chris Christoffersen, Partner, Morgenthaler Ventures Ken Collins, President, Replidyne Tim Conner, Partner, Sequel Ventures Dave Cook, Counsel, Faegre & Benson Lu Cordova, President, Colorado Technology Incubator (CTEK) Jerry Donahue, President, University License and Equity Holdings, Inc. Dee Dee LeGrande, CEO, BRW Legrand Kyle Lefkoff, Managing Partner, Boulder Ventures Jim Linfield, Managing Partner, Cooley Godward Dallas Martin, Vice President and General Counsel, SwitchPoint Networks, Inc. Bill Mooz, VP, International Business Development, Sun Microsystems Bob Olsen, Executive Director, Fitzsimmons Redevelopment Authority Gary Powell, Partner, KPMG Juan Rodriquez, Co-founder of StorageTek and Exabyte Kathy Simon, Director, Deming Center for Entrepreneurship, CU, Boulder Don VanLandingham, past CEO/President, Ball Aerospace Four Faculty Contributors: Bill Arend, Rheumatology and Boris Tabakoff, Pharmacology, HSC; Bob Erickson and Garrett Moddel, CU Boulder, Engineering Introduction Mission Capabilities Goals Technology Licenses Start ups Successes Questions

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