PARKINSON’S DISEASE. Sarah Newport. Background . Historians have found evidence of the disease as far back as 5000 B.C. (Ayurveda , an ancient Indian medical practice) “ Kampatava ” It was first described in “An Essay on the Shaking Palsy " in 1817 by English physician James Parkinson
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-Substantial Nigra =>Nigrostriatal pathway => Corpus Striatum
L-tyrosine >>> L-dopa >>> Dopamine
Progression of Parkinson's as seen on PET scans=>
-some people have an inherited susceptibility to the disease that may be influenced by
-slowness of movement
-Pharmacological: Levodopa (L-DOPA), dopamine agonists, MAO-B inhibitors