Parkinson s disease
1 / 16

PARKINSON’S DISEASE - PowerPoint PPT Presentation

  • Uploaded on

PARKINSON’S DISEASE. Sarah Newport. Background . Historians have found evidence of the disease as far back as 5000 B.C. (Ayurveda , an ancient Indian medical practice) “ Kampatava ” It was first described in “An Essay on the Shaking Palsy " in 1817 by English physician James Parkinson

I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
Download Presentation

PowerPoint Slideshow about ' PARKINSON’S DISEASE' - lenora

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.

- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
Parkinson s disease


Sarah Newport


  • Historians have found evidence of the disease as far back as 5000 B.C. (Ayurveda, an ancient Indian medical practice)

  • “Kampatava”

  • It was first described in “An Essay on the Shaking Palsy" in 1817 by English physician James Parkinson

  • 1861:French neurologist Jean Martin Charcot distinguished the disease from other neurological conditions and deemed it "Parkinson's disease."


Brief overview
Brief overview

  • Parkinson's disease (PD) is a neurological condition

  • Chronic and progressive movement disorder

  • Degeneration of the basal ganglia

    -Substantial Nigra =>Nigrostriatal pathway => Corpus Striatum

Causes of parkinson s disease
Causes of parkinson’s disease

  • Mainly idiopathic ! (aforementioned massive loss of cell activity)

    L-tyrosine >>> L-dopa >>> Dopamine

Progression of Parkinson's as seen on PET scans=>

Causes of pd cont
Causes of pd (cont.)

  • Neurotransmitter dopamine serves many functions including the influence of movement, learning, attention, and emotion

  • reduced dopamine receptor activity linked to PD symptoms (brain produces tremors, decreased mobility)

  • Parkinson's patients have a loss of 80 percent or more of dopamine-producing cells in the substantianigra

  • The reduction in dopamine leads to cell damage (cell damage does not initially reduce dopamine formation)

  • patients with PD show increased brain levels of iron, especially in the SN, and decreased levels of ferritin, which serves as a protective mechanism

  • when dopamine is not properly formed, the toxic element Superoxide ion can form instead, resulting in oxidative damage to mitochondria (energy producing organelles of the cell), causing death of the cell

More on pd pathogenesis
More on pd pathogenesis

  • Genetic influence

    -some people have an inherited susceptibility to the disease that may be influenced by

    environmental factors:

    -Toxic causes

    -Head trauma

    -Drug induced

Pd symptoms
Pd symptoms

  • Cardinal motor symptoms:



    -slowness of movement

    -postural instability

Other pd symptoms
Other pd symptoms

  • Neuropsychiatric disorders of speech, cognition, mood, behavior, and thought

  • Depression and anxiety are common in patients. Dementia or confusion can develop in the later stages of Parkinson’s disease. Some patients experience a decreased sense of smell.

  • Sleeping problems

  • ANS


  • 2nd most common neurodegenerative disorder to Alzheimer’s

  • .3% of population in industrialized countries

  • >6 million people worldwide, even more undiagnosed

  • >1 million Americans

  • Primarily strikes ages 50+

  • Average onset age=60 yrs

  • Prevalence and incidence increase with age

  • Rare amongst the very young and old

  • M>F

  • Generally more PD cases of Whites than Latinos or Blacks in the United States


  • There is no one particular test that can be done to diagnose Parkinson's Disease

  • Diagnostic techniques range from genetic testing, testing of the olfactory and autonomic system, neurophysiological testing and neuroimaging.


  • There is no known cure for Parkinson’s

  • Therefore, treatment is symptomatic

  • Quality of life deteriorates quickly if treatment is not instituted at or shortly after diagnosis

  • Medications and/ or surgery can provide symptom relief, to an extent

    -Pharmacological: Levodopa (L-DOPA), dopamine agonists, MAO-B inhibitors

  • drugs for Parkinson's Disease can be both a cure and eventual cause of symptoms

Treatment cont
Treatment cont.

  • broad-based management: patient and family education, support group services, general wellness maintenance, and nutrition

  • Living with Parkinson's disease: denial, helplessness, anger, fear, withdrawal from social circles are coping mechanisms

  • Depression is very common in patients with PD

  • Utilization of psychological services proven helpful

  • Palliative care