A Service Evaluation of Procalcitonin after PRORATA. Daniel Cottle DICM John Butler, Tony Dunne, Sanchia Pickering Manchester Royal Infirmary 2011. Antimicrobial resistance in ICU. CPC MRSA. Antimicrobial resistance in ICU.
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Daniel Cottle DICM
John Butler, Tony Dunne, Sanchia Pickering
Manchester Royal Infirmary 2011
Reducing antibiotic use may contain the emergence of multi-drug resistance bacteria in ITUs.
Stop inappropriate prescribing.
Shorten duration of treatment of antibiotics.
Calcitonin in healthy persons
PCT in bacterial infection
Müller B. et al., JCEM 2001
Fast increase of PCT after bacterial challenge
Brunkhorst FM et alIntens Care Med 1998; 24:888-892
Source: The Lancet 2010; 375:463-474 (DOI:10.1016/S0140-6736(09)61879-1)
Terms and Conditions
60 antibiotic episodes
8 to the ward
4 escalated despite
29 stopped early
1 escalated because
8 no difference