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中藥處方對肝病療效之研究

中藥處方對肝病療效之研究. ”當歸龍薈丸”及傳統中醫臨床治療肝炎處方之一,可惜缺乏生藥或藥理學之佐證。 本論文採用四氯化碳誘發小白鼠肝障礙之病態動物模式,鑑定本處方之保肝效果,並 進而做有效成分之分析及定量,以為臨床運用本處方及品管分析之參考。 研究顯示,歷代收載之”當歸龍薈丸”中以宣明論文水抽取物口服之保肝效果最佳。 至於其組成各單味藥物之活性,以黃芩 (Scutellaria baicalensis Georgi) ,大黃 (Rheum palmatum L.) 黃連 (Coptis chinensis Franch) ,當歸 (Angelica sinensis

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中藥處方對肝病療效之研究

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  1. 中藥處方對肝病療效之研究 • ”當歸龍薈丸”及傳統中醫臨床治療肝炎處方之一,可惜缺乏生藥或藥理學之佐證。 • 本論文採用四氯化碳誘發小白鼠肝障礙之病態動物模式,鑑定本處方之保肝效果,並 • 進而做有效成分之分析及定量,以為臨床運用本處方及品管分析之參考。 • 研究顯示,歷代收載之”當歸龍薈丸”中以宣明論文水抽取物口服之保肝效果最佳。 • 至於其組成各單味藥物之活性,以黃芩(Scutellaria baicalensis Georgi),大黃 • (Rheum palmatum L.) 黃連(Coptis chinensis Franch) ,當歸(Angelica sinensis • Diels)效果較顯著,且其中又以黃芩之保肝效果最強,但仍小於全方之複合效果。另 • 由黃芩單離出四種類黃鹼素化合物(Flavonoid Compound)即Baicalin,Berberine , • Woogonin,Oroxylin-A,均顯示有大小不等之保肝作用,因此初推定為黃芩及本處方 • 之有效成分之一。 • 應用柱狀曾析及薄層層析配合生物檢定,追蹤分析本處方之有效分劃部分即DEB-1 , • DECM-1,DECM-6,並利用薄層色層分析掃描儀(CS-930)及高速液相色層分析儀,作有 • 效主成份之定性、定量試驗,分別測出含有Chrysophanol,Emodin,Woogonin, • Baicalin,Berberine , 並於本論文中詳細討論其對肝障礙之抑制效果。

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