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Avrio Medical

Avrio Medical . Small Heart EKG Arrhythmia Research Tool Cardiac Mapping - Microvolt Signal Acquisition Seddrak Luu George Kwei Jeff Chang Joe Ma Eric Chow Kenny Pak. Overview. Business aspect Marketing Cost Technical aspect Hardware Software. Arrhythmia.

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Avrio Medical

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  1. Avrio Medical Small Heart EKG Arrhythmia Research Tool Cardiac Mapping - Microvolt Signal Acquisition Seddrak Luu George Kwei Jeff Chang Joe Ma Eric Chow Kenny Pak

  2. Overview • Business aspect • Marketing • Cost • Technical aspect • Hardware • Software

  3. Arrhythmia • Junctional Ectopic Tachycardia • Disorders of the regular rhythmic beating of the heart • Occur in children after open heart surgery • 1 in 10 infant goes into arrhythmia after open heart surgery • Can be lethal

  4. The Big Picture • understanding the patho-physiology of JET

  5. Goal • a Small Heart EKG System to help understand the Arrhythmia • Focus on helping those in need rather than actual profit

  6. Executive Team Seddrak Luu Jeff Chang Joe Ma George Kwei Eric Chow Kenny Pak

  7. BCRI Correspondence • Dr. Glen Tibbits • Director Cardiovascular Sciences Professor of Kinesiology, Simon Fraser University (SFU) • Helen Sheng (Graduate Student, MD) • Eric Lin (Graduate Student)

  8. Other Sources of Information • Margaret Evans, • Advanced Measurements • Andrew Pruszynski • Wireless Medical Devices, TA • SFU Faculty • School of Kinesiology/Engineering

  9. Structure of the Project • Signal Retrieval Stage • Signal Transmission • Signal Processing • Signal Analysis

  10. Avrio Core Business 1. Small Heart EKG - commercial introductions expected in a few years. Business Based on the Product 2. Platinum Electrode Tips 3. Customize Circuitry to suit the need 4. Customize the Labview Interface

  11. Business • Current Client • Dr. Glen Tibbits of BC Research Institute of Chilrdren’s and Women’s

  12. Statistics • In British Columbia, ~40,000 babies were born* • 600 babies are born with congenital heart disease • Of that about 200 will require open heart surgery • 1 in 10 will go into Arrhythmia *From Statistics Canada

  13. Market Strategy (Short Term) • Short Term • Research Based Institute • Children Hospitals and Children Research Institute

  14. Marketing Strategy (Long Term) • Long Term • Organization that supports the developing countries • United Nation • Unicef • Engineers / Doctors Without Borders • Aim for developing countries trying to do heart research with minimal budget

  15. Improvements • Electrode Grid with more electrode • Increase number of electrodes per grid • Tailor specific small EKG and interface for specific customerdepending on the type of heart

  16. Prototype • Total Cost: $ 751.16 • Research: $ 134.01 • Electrodes, Gel, Gel Pad • Material: $ 575.29 • Wires, Breadboard, Necessary Components • Shipping: $ 41.86

  17. Product Price for Small Heart EKG Component Price • 24 x AD620 $6.00 • 4 x TL072 $1.00 • Capacitors / Resistors $15.00 • Wiring (Copper) $1.00 • Wiring (Platinum) $4.00 • Breadboard $20.00 • Batteries $3.00 • Miscellaneous and Casing $5.00 • NET PRODUCT PRICE $58.80 • Labour (6 hours) $72.00 • Labview Interface $39.00 • TOTAL $169.80

  18. Technical Aspects of Avrio Small Heart EKG

  19. Heart Setup • Preparation of the heart • Biology of the heart

  20. Video of the Heart • Here we present some excerpts of the in lab trials of our designed device.

  21. Electrodes • Initial Design Concepts/Problems • A grid system • Compact • Isolated • A flexible wrap

  22. Electrodes

  23. Electrodes • Final Design • Coiled platinum electrode tips • Grounded Tin Foil Shielding • Braided wires with metallic shielding

  24. Electrodes

  25. Challenges Incurred • Electrode Tip • Size & Weight • Crosstalk • Interference • Positioning Electrodes

  26. Challenge: Electrode Tip • Type of material necessary • Amount of surface contact • Physical spacing of electrodes • # of possible electrode tips

  27. Challenge: Size & Weight • 2-5 grams • 1.5x1.5x1.5 cm dimensions • This is a very small testing area. • We were only able to use ¼ of the heart surface for relevant probing data.

  28. Challenge: Crosstalk • Crosstalk aka additive/subtractive signals • This is caused by close proximity of the electrode • Solution: • Only preventative measures such as spacing of electrode tips could be used • Future versions of systems will have software solution to this problem

  29. Challenge: Interference • Outside electrical sources such as power lines and light bulbs • Most common is the 60Hz noise • Seen from the building power lines • Solution: • Cross braiding of the electrode leads • A metal shielding from artificial light

  30. Challenge: Positioning Electrodes • Initially we hand probed the heart as an initial step. • This was sufficient for testing but not very accurate. • Solution: • A mounting device for the electrode bundle • Needed to carefully hand manipulate the electrode tips so that they made no contact with each other.

  31. Signal Conditioning Circuitry • Provide Gain • Heart signal is low-milli to high-micro Volt range • Filtering • Get rid of noise from environment and other lab equipment

  32. The Circuit

  33. Circuit Design • AD620 has high Input Impedance • Low power, low cost • -40dB Filter • Filtering Cutoff Frequencies at 15Hz

  34. A/D • National Instrument BNC-2090 • National Instrument AT-MIO-16E-10

  35. Labview • Testing • Signal Acquisition • Signal Conditioning • Signal Analysis

  36. Labview: Simulating the Heart • Generate small heart signals • Generate background noise

  37. Labview: Acquiring Data • Write data to file • Filter acquired data • Show frequency domain

  38. Ischemia • Inverted T-wave

  39. Bundle Branch Block • Wide QRS Complex • Caused by activation of the left ventricle prior to activation of the right ventricle

  40. Atrial Flutter • Wide QRS complex • Inverted T-wave: Ischemia • Short PR-PR intervals • “saw tooth” pattern

  41. Bundle Branch Block • Wide QRS Complex • Caused by activation of the left ventricle prior to activation of the right ventricle

  42. Ventricular Tachycardia • AV dissociation, no relationship between P-wave and QRS complex • Wide QRS

  43. Final Comments • What we learned from this: • Biological Structure of the heart • Biological Signal Processing • Signal Acquisitio • Hardware Filtering • Software Analysis

  44. Signs of Success • We learned a lot about biology,software and hardware. • We were able to obtain usable small signals that could be analyzed. • Finally • We started with 6 group members and we still have 6 group members. YAY!

  45. Contacts • Company Website: www.sfu.ca/~sluu/avrio • Company Email: • ensc340-wireless@sfu.ca

  46. Questions? • Comments

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