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Genital tract HPV types: LOW RISK: 6, 11, 40, 42, 43, 44; PowerPoint Presentation
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Genital tract HPV types: LOW RISK: 6, 11, 40, 42, 43, 44; - PowerPoint PPT Presentation


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Genital tract HPV types: LOW RISK: 6, 11, 40, 42, 43, 44; INTERMEDIATE RISK: 31, 33, 35, 51, 52; HIGH RISK: 16, 18, 45, 56. HPV-Induced Oncogenesis: Viral Events Integration at the E2 site leads to its deactivation and release of E6 and E7 gene inhibition.

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slide6

Genital tract HPV types:

LOW RISK: 6, 11, 40, 42, 43, 44;

INTERMEDIATE RISK: 31, 33, 35, 51, 52;

HIGH RISK: 16, 18, 45, 56

slide7

HPV-Induced Oncogenesis: Viral Events

Integration at the E2 site leads to its deactivation and release of E6 and E7 gene inhibition

slide8

HPV-Induced Oncogenesis: Cellular Events

E6 binds to p53 and induces its degradation. E7 binds the Rb gene product, causing the transcription factor E2F-1 to become unbound and free to induce cell cycle activation/growth.

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This algorithm generally depicts standard management options for abnormal Pap smears. Options include management of the first ASCUS smear and management of low-grade lesions (LGSIL). Atypical glandular cells of undetermined significance (AGCUS) should lead to consideration of colposcopy, endocervical curettage (ECC), and possibly cone biopsy (Bx).