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Codon optimization in the middle region of FRQ hinders phosphorylation and enhances its stability, as observed in a study by M. Zhou et al. in Nature (2013). This process affects the regulation of FRQ's functions.
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Codon optimization of the middle region of FRQ impairs FRQ phosphorylation and stabilizes FRQ. M Zhou et al. Nature 000, 1-5 (2013) doi:10.1038/nature11833