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By Suat Kucukgoncu Elton Zhou Katherine Lucas Cenk Tek

Alpha-Lipoic Acid (ALA) as a S upplementation for W eight L os s : Results from a Meta-Analysis of Randomized Controlled Trials. By Suat Kucukgoncu Elton Zhou Katherine Lucas Cenk Tek. Powerpoint by Jemima Jennyl B. Baquiran, DMD. Introduction.

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By Suat Kucukgoncu Elton Zhou Katherine Lucas Cenk Tek

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  1. Alpha-Lipoic Acid (ALA) as a Supplementation for Weight Loss: Results from a Meta-Analysis of Randomized Controlled Trials By Suat Kucukgoncu Elton Zhou Katherine Lucas Cenk Tek Powerpoint by Jemima Jennyl B. Baquiran, DMD

  2. Introduction

  3. There are 1.8 billion overweight individuals and around 600 million obese adults. With consumerism, fast food chains, and easy to prepare meals are a must in this fast paced life-what people eat and how healthy it was are of less importance as years go by.

  4. Obesity is now a worldwide epidemic that is growing attention due to its association with cardiovascular diseases and diabetes. It is linked with propensity in regards to mortality and morbidity rates.

  5. Alpha lipoic acid (ALA) is a powerful antioxidant and a free radical scavenger. It is sold commercially over-the-counter as a nutritional antioxidant supplement, alone or in combination with other antioxidants. • In animal studies, ALA has been shown to promote the reduction of body weight and fat mass by decreasing food intake and enhancing energy expenditure. With such results, it was thought that in human form, ALA could possibly yield the same results.

  6. Relevance

  7. Weight loss has been associated with prevention of diabetes, reduction in blood pressure, lowered cholesterol and triglyceride levels, and other health benefits. ALA has been linked in other studies, its anti-obesity and beneficial diabetic neuropathic properties.

  8. Objectives

  9. The study aims to systematically review and perform comprehensive meta-analysis to assess the effects of ALA as a weight-loss supplement on weight and body mass index.

  10. Highlights

  11. From hundreds of articles, it was narrowed down to 11 eligible articles. The total number of participants in these studies was 534 for the ALA group and 413 for the placebo group. The study durations were between 8 weeks to 52 weeks. ALA doses were between 300 mg/day to 1800 mg/day • In summary, overall weight loss was 1.27 kg greater in ALA treatment compared to that in placebo group.

  12. A significant overall mean BMI difference was found -0.40 kg/mm between the ALA and placebo groups. • For weight loss interventions, no found significant difference on effectiveness of ALA in weight loss interventions compared to those non-weight loss interventions. Cumulative analysis of BMI reduction in weight loss interventions was similar to those non-weight loss interventions.

  13. Whereas in diet intervention, no significant difference between body weight changes in ALA with diet intervention studies compared to those only ALA intervention studies. Cumulative analysis of BMI reduction in ALA with diet intervention were similar to those ALA without diet intervention.

  14. According to one study conducted by Koh et al., the effects of 1200 mg/day and 1800 mg/day ALA intervention on body weight loss was studied. They found the higher dose of ALA resulted in significant weight loss and BMI reduction. The lower dose of ALA led to significant weight loss in the first weeks of this study, however this effect was not sustainable through the entire duration of the study. From these findings,it is safe to say that the effect of ALA on body weight is limited to the short term, especially at lower doses with an adaptation mechanism taking over later.

  15. In regards to safety, not much has been reported alarmingly. Only three studies reported side effects and withdrawal symptoms, most commonly reported were gastrointestinal symptoms of abdominal pain and nausea, and dermatological symptoms, such as urticaria and itching sensation. ALA has been well tolerated and has no serious side effects whatsoever.

  16. Conclusion

  17. ALA may be considered a useful supplement, showing limited, yet significant short-term weight loss. For overweight and obese individuals- more comprehensive research is needed for the dosage, dosage effects, and long term benefits of ALA supplementation on weight management.

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