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Distinct Components of Spatial Learning Revealed by Prior Training and NMDA Receptor Blockade. D.M. Bannerman, M.A. Good, S.P. Butcher, M. Ramsay & R.G.M. Morris. GROUP A3 Bonnie Chan | Anastasia Christopher | Herman Gill Marisa Leung | Sarah McNeil | Carol Rego. Carol Rego.

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distinct components of spatial learning revealed by prior training and nmda receptor blockade

Distinct Components of Spatial Learning Revealed by Prior Training and NMDA Receptor Blockade

D.M. Bannerman, M.A. Good, S.P. Butcher, M. Ramsay & R.G.M. Morris

  • GROUP A3
  • Bonnie Chan | Anastasia Christopher | Herman Gill
  • Marisa Leung | Sarah McNeil | Carol Rego
table of contents

Carol Rego

Table of Contents
  • Overall Evaluations
  • Methodological Critiques
    • Unexplored Pathway of LTP
    • Age and Gender Anomalies
    • Pharmacological Side Effects
  • Alternate Interpretation of the Results
  • Further Exploration
slide3

Carol Rego

Overall Evaluations

  • The purpose of the study was very non specific, which allowed for further exploration during the course of the study.
overall evaluations1

Carol Rego

Overall Evaluations

NMDA receptors are not necessary for all hippocampus dependant spatial learning, but NMDA receptor dependant plasticity is dependent on the hippocampus for its expression.

unexplored pathway of ltp

Herman Gill

Unexplored Pathway of LTP
  • Study focused on hippocampus
  • Actually three different pathways
unexplored pathway of ltp2

Herman Gill

Unexplored Pathway of LTP

Perforant

Mossy Fibre

Schaffer Collateral

unexplored pathway of ltp3

Herman Gill

Unexplored Pathway of LTP

LTP is NMDA-independent in mossy fibre pathway

Perforant

Mossy Fibre

Schaffer Collateral

unexplored pathway of ltp4

Herman Gill

Unexplored Pathway of LTP
  • In CA1 and DG
    • NMDA responsible for LTM retrieval
  • In CA3
    • NMDA responsible for spatial recognition

LTM Retrieval

Spatial Recognition

age anomalies

Bonnie Chan

Age Anomalies
  • Difference in performance with regards to age
  • Declines continuously beginning at earliest age
pharmacological side effects

Bonnie Chan

Pharmacological Side Effects
  • Common critique/concern
  • Effects of the drugs used to block NMDA receptors not well researched
  • Side effects may cause a decrease in performance
    • (i.e.) due to drowsiness, disorientation
  • Solution  Gene knockout?
alternate interpretation

Anastasia Christopher

Alternate Interpretation
  • Stress Impairs Performance in Spatial Water Maze Learning Tasks (1999)
    • By Christian Holscher
alternate interpretation1

Anastasia Christopher

Alternate Interpretation
  • Stressful situations
    • Stress can impair performance on specific activities
  • How altered fear conditions and stress perception can account for the impaired spatial learning
alternate interpretation2

Anastasia Christopher

Alternate Interpretation
  • Findings:
    • Stress can cause amnesic symptoms in working memory
    • Non-handled rats were slower in a spatial learning task
alternate interpretation4

Anastasia Christopher

Alternate Interpretation
  • Connection:
    • Alternative interpretations for this research paper
      • Experiment 2  no deficit; handling
      • Experiment 3  stress was not an issue
      • Experiment 4  extramaze cues
further studies conclusion

Sarah McNeil

Further Studies – Conclusion

There is lots of evidence to suggest that LTP might be similar to the neural mechanism that the brain uses in learning and memory but the conclusion can not be made that the mechanisms are the same.

this concludes our presentation

This concludes our presentation

We will be happy to address any questions you may have