HCVM. Member of b -herpesvirus family >200 ORFs Genes are expressed in a regulated cascade Some fulfill regulatory functions pUL38 expression during early phase pUL38 blocks apoptosis. http://www.abbottdiagnostics.co.uk. Tuberous Sclerosis Complex. Autosomal dominant disorder
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Due to inactivating mutations in TSC1 or TSC2
Fibroblast, 0.01 PFU/cell, 0-10 dpi
~ 50 target proteins
Fibroblast, 3 PFU/cell, 48 hrs p.i.
293T, Transfection of a vector expressing pUL38, 48 hrs p.t.
BADinUL99GFP, 0.1 PFU/cell, 24 hrs p.i.
pUL38 interact via TSC2 with the TSC1/2 complex following infection with a
Ectopic expression of pUL38 in fibroblasts increased their size
Interaction of pUL38 with TSC1/2 blocked its ability to regulate mTORC1 in response to stress outside the context of infection
In the presence of pUL38, AMPK stimulation did not block phosphorylation of rpS6Summary
MS/MS: Tandem Mass spectometry