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Viral tropism by geno2pheno as a tool for predicting CD4 decrease in HIV-1 infected naïve patients with high CD4 counts.

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Viral tropism by geno2pheno as a tool for predicting CD4 decrease in HIV-1 infected naïve patients with high CD4 counts

Nozza S1, Canducci F2, Galli L1, Cozzi-Lepri A3, Capobianchi MR4, Ceresola E2, Antinori A3,4, Di Giambenedetto S3,5, D’Arminio Monforte A3,6, Castagna A1 ,3 and ICONA Foundation

1 Department of Infectious Diseases - IRCCS San Raffaele, Milan, Italy

2 Laboraf, San Raffaele Scientific Institute, Milan, Italy

3 ICONA Foundation,Italy

4 IRCCS Spallanzani, Rome, Italy

5 Catholic University, Rome, Italy

6AziendaOspedaliera San Paolo, Milan, Italy

TUPDB0103

aim of the study
AIM OF THE STUDY

METHODS

To investigate the value of a geno2pheno estimate of viral tropism in predicting CD4+ depletion in HIV-infected naive subjects with high CD4+.

Multicenter, cohort study with retrospective assessment of viral tropism on stored plasma samples

  • Included HIV-1 naive infected patients with:
        • CD4+>350 cells/mm3 at time of first sample
        • HIV-RNA>500 copies/mL
  • Follow-up time ranged from the date of first available plasma sample (baseline) to the date of the last visit or the date of cART initiation.
  • HIV-1 coreceptor usage was determined by algorithm geno2pheno, available at http://coreceptor.bioinf.mpi-inf.mpg.de/, with a cut-off of false-positive rate (FPR) of 10%.
baseline characteristics
Baseline characteristics

Median values (IQR) or n (%)

slide4

Fig 2 CD4 Decrease according to gender

Fig 1 CD4 Decrease according to viral tropism

P=0.255

P=0.038

Median (IQR) CD4+ change:

-133 (-272/+0.5) cells/µL

Median (IQR) CD4+ change:

-166(-284/-60) cells/µL

Median (IQR) CD4+ change:

-150(-276/0) cells/µL

Median (IQR) CD4+ change:

-218 (-281/-143) cells/µL