ANNOUNCEMENTS:. Proposal first drafts are due Thursday, 11/12. You may turn it in as late as 11/19, without penalty, however, drafts received after 11/13 may not be reviewed prior to the Thanksgiving break. Primary Papers for this week.
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Proposal first drafts are due Thursday, 11/12. You may turn it in as late as 11/19, without penalty, however, drafts received after 11/13 may not be reviewed prior to the Thanksgiving break.
Riddle, Johnson, Laufer, and Tabin (1993). Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75:1401-1416.
Litingtung, Dahn, Li, Fallon, and Chiang (2002). Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity. Nature 418:979-983.
Neural crest cells and axonal specificity
(A) In the absence of UNC5 proteins, netrin-1 causes a change (perhaps conformational) in DCC that results in the recruitment of some adaptor proteins (Y and Z) but not others (W). A “coreceptor for attraction” (“X?”) may be recruited and necessary as well (see text).
(B) In the presence of UNC5 proteins, changes (perhaps conformational) in both the UNC5 and DCC proteins result in the interaction of their cytoplasmic domains and consequently the recruitment of a different complement of adaptors (Y and W, not Z). It may also involve exclusion of a putative coreceptor for attraction. The diagram is drawn as if the DB and P1 domains interact directly, but this has not been shown.
Vertebrate Limb Development