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A Quick Guide to NIH Grants for Early Stage and New Investigators

A Quick Guide to NIH Grants for Early Stage and New Investigators. Alan Embry Program Officer Division of AIDS, NIAID, NIH embrya@mail.nih.gov. R03. Diversity Supplements. K22 Research Scholar Development Award. Transition award for postdocs moving to positions of assistant professor

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A Quick Guide to NIH Grants for Early Stage and New Investigators

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  1. A Quick Guide to NIH Grants for Early Stage and New Investigators Alan Embry Program Officer Division of AIDS, NIAID, NIH embrya@mail.nih.gov

  2. R03 Diversity Supplements

  3. K22Research Scholar Development Award • Transition award for postdocs moving to positions of assistant professor • Must have less than 5 years postdoctoral experience • Two-phased application • Phase 1 • Scientific merit • No institution yet • If applicant gets a fundable score, they have a year to find a position as assistant professor • Phase 2 • Assistant Professor • Own lab • Significant start-up funds • Little teaching/no administrative responsibilities http://grants.nih.gov/grants/guide/pa-files/PAR-09-068.html

  4. K99/R00 Pathway to Independence Award • Transition award for postdocs moving to assistant professor positions • Must have less than 5 years postdoctoral experience • Has mentored phase • Citizenship and green card not required- new feature for any K • Has a mentored phase (K99) and an independent phase (R00) • NIAID committed to only six awards http://grants2.nih.gov/grants/guide/pa-files/PA-10-063.html

  5. K22 and the K99/R00 Award Features K22 • 2 yr award • No mentored phase • Awardee gets funds at the time of becoming asst. professor • $150K (year 1) direct costs + $100K (year 2) direct costs + 8% F&A K99/R00 • 3 year award only • Up to 1 yr mentored phase ($90K/yr) • Awardee becomes asst. professor- No peer review • 2 yr independent R phase ($249K/yr TC)

  6. Timeline from Postdoc to Assistant Professor Apply For K22 or K99 Re-apply If needed R01 Promotion Tenure K22 or K99 PhD or EOT for MDs Postdoc Assistant Professor ~11 Yrs 0 Yrs 5 Yrs

  7. Career Award Selection http://grants.nih.gov/training/kwizard/index.htm

  8. Average Age of First Time R01 Equivalent

  9. Early Stage Investigator Status • An ESI is a scientist who is within 10 years of either of the following: • Terminal research degree • Medical residency or equivalent • You can request an extension of your ESI status past the 10-year • window due to special circumstances. • Keep in mind that on a multiple PI application, all PIs must qualify as • new or ESI for the application to get either status. http://funding.niaid.nih.gov/ncn/grants/new/portal.htm

  10. New Investigator Status • A new investigator is a scientist who has not previously received a • significant independent NIH Research Award. The following are • grants that do not affect NI status: • R00 • R03 • R15 • R21 • R34 • R56 • Fellowships (F) • Career Development (K) • Loan Repayment (L30, L32, L40, L50, L60) • Training Grants (T32, T34, T35, T90, D43) http://grants.nih.gov/grants/new_investigators/index.htm#definition

  11. NIAID Success Rates by Mechanism in 2008 K22 – 19.2% (10) R99 – 7.5% (6) K08 – 49.3% (37) R03 – 22.1% (58) R21 – 21.3% (266) R01 – 20.7% (533) http://report.nih.gov/

  12. Eligibility and Salary Questions • Q: If ESIs receive stimulus funding will they still have ESI status? • A: It depends on the mechanism of ARRA support. • Q: When you have a K award, what are restrictions of receiving salary with • other NIH grants? • A: You cannot receive salary from any other source of federal funds. • Q: How can we apply for other NIH awards with no salary in the budget? • A: Some K awards allow for the potential to apply for R01s and obtain • salary support in the last 2 years of the grant (i.e. K08). You can be • on another PI’s grant with effort but no salary. • Each K award is slightly different. Check the K Kiosk website for details • or contact a program officer with questions: • http://grants.nih.gov/training/careerdevelopmentawards.htm

  13. Grants and the NIH Peer Review System

  14. NIH Grant Info Resources http://funding.niaid.nih.gov/ncn/grants/default.htm

  15. “I don’t really care about that administrative stuff!”IMPORTANT: • Understand how NIH works • Easy to disengage and only focus on the lab • Network with NIH staff • Talk to us at meetings, on the phone, by email • If I don’t know you, how can I help you? • Understand how NIH peer review works • Learn what works and what doesn’t in peer review and funding

  16. Where are applications reviewed? • CSR • Study Sections • Research Project Grants (R01s) • AREA Grants (R15s) • Fellowships (F32s & F31s) • SBIRs • Shared Instrumentation Grants • Small Grants (R03s) • Exploratory/Developmental Grant (R21s) • INSTITUTES • Scientific Rev. Grps. • Contract Rev. Ctees. • Program Project Grants (P01s) • Center Grants (P30s) • Training Grants (T32s) • K Grants • RFAs (some of which will be for R01s) • Contracts

  17. What happens to my application at NIH? Submission of application CSR CSR Referral Office CSR Study Section Institute Review Ctee. Advisory Council INSTITUTE FUNDING DECISION NGA

  18. Common Pitfalls for Young Investigators • Proposed project is not novel or innovative • Even if project is successful will have questionable impact to the field • Failure to convince reviewers of scientific rational for proposed studies • Research is mainly descriptive or correlative –’looking at’ bad, testing good • Lack of clear, testable hypothesis – ‘fishing expedition’ • Inadequate preliminary data to support a large investment • Unfocused research plan • Lack of experience in the proposed methodology • Insufficient publication record • Uncertainty concerning the future directions • Failure to consider potential pitfalls/alternative approaches • Unrealistically large amount of work • Lack of statistical considerations

  19. New Grant Format http://enhancing-peer-review.nih.gov/restructured_applications.html

  20. Specific Aims • The most critical page in the application • It is a one page summary of the application • Why is this problem significant? • What is the exciting preliminary data? • What are the hypothesis supported by the data? • How will this project significantly impact the field? • Make sure to emphasize important points that you absolutely want the review to know • Make them want to keep reading • Simple list of your Aims is good • Be general • Avoid long list of things you are going to do http://enhancing-peer-review.nih.gov/restructured_applications.html

  21. REVIEW CRITERIA: • Significance • Approach • Innovation • Investigator • Environment

  22. Review and Scoring What do reviewers look for when reading your grant? http://enhancing-peer-review.nih.gov/guidance_reviewers.html

  23. Don’t give up! • Initial failure is common • Learn from a failed submission and succeed • Study criticisms in summary statement • Decide if problems are repairable • Carefully address each criticism • Keep a positive tone and attitude • Introspection is important – be willing to critically question your research and future directions

  24. Helpful websites NIAID training and career awards information http://funding.niaid.nih.gov/ncn/training/default.htm New and ESI http://funding.niaid.nih.gov/ncn/grants/new/portal.htm Revised New and Early Stage Investigator Policies http://grants.nih.gov/grants/guide/notice-files/not-od-09-013.html K Kiosk http://grants.nih.gov/training/careerdevelopmentawards.htm Reduction in effort for K-awardees: http://grants.nih.gov/grants/guide/notice-files/not-od-08-065.html Enhancing Peer Review at the NIH – Table of Page Limits effective Jan 25th, 2010 http://enhancing-peer-review.nih.gov/page_limits.html Standard receipt/due dates http://grants.nih.gov/grants/funding/submissionschedule.htm Organization of DAIDS: http://www3.niaid.nih.gov/about/organization/daids/

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