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Investigating PSD-95 Interaction with Tubulin: Impact of Nicotine Exposure

This study explores the effects of nicotine exposure on PSD-95 interaction with tubulin through ab oligomers. Various experimental conditions like a-Btx and Wortmannin are examined to understand the molecular implications. Supplementary data provides further insights.

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Investigating PSD-95 Interaction with Tubulin: Impact of Nicotine Exposure

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  1. A PSD-95 tubulin 1.5 1.0 PSD-95 (r.u) 0.5 0 - - - + + + Ab oligomers - - - + + + Nicotine - - - - + + a-Btx B PSD-95 tubulin 2.0 PSD-95 (r.u) 1.0 0 - + + + + Ab oligomers - - + + + Nicotine - - - - + Wortmannin - - - - + BSD C PSD-95 tubulin 1.0 PSD-95 (r.u) 0.5 0 - - - + + + Ab oligomers - - - + + + Nicotine - - - - + + DHbE Supplementary S1

  2. A Control Control Wild Wild type type Nicotine Nicotine Wild Wild type type B Supplementary S2

  3. A a b B Ab fibrils Ab+Nicotine (100 mM; 24h) Supplementary S3

  4. A * B * C Supplementary S4

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