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OVEREATING STUDIES (individual subjects). Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971. OVEREATING STUDIES (individual subjects). Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971. OVEREATING STUDIES (individual subjects).

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Salans l b et al journal of clinical investigation 50 1005 1011 1971

OVEREATING STUDIES

(individual subjects)

Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.


Salans l b et al journal of clinical investigation 50 1005 1011 1971

OVEREATING STUDIES

(individual subjects)

Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.


Salans l b et al journal of clinical investigation 50 1005 1011 1971

OVEREATING STUDIES

(individual subjects)

Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.


Salans l b et al journal of clinical investigation 50 1005 1011 1971

OVEREATING STUDIES

(individual subjects)

Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.


Salans l b et al journal of clinical investigation 50 1005 1011 1971

OVEREATING STUDIES

(individual subjects)

Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.


Salans l b et al journal of clinical investigation 50 1005 1011 1971

OVEREATING STUDIES

(individual subjects)

Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.


Salans l b et al journal of clinical investigation 50 1005 1011 1971

Inflammation

Insulin Resistance

↓ NO

Insulin Resistance

↓ Fibrinolysis

Vasoconstriction

TNF α

Insulin

Resistance

IL-6

PAI-1

Resistin

Angiotensin

Insulin Resistance

Adiponectin


Salans l b et al journal of clinical investigation 50 1005 1011 1971

NUTRITION IN OBESITY

Percent Fat

Caloric Intake


Salans l b et al journal of clinical investigation 50 1005 1011 1971

OBESITY

Sedentary Pair Weighted

Sedentary Free Eaters

Exercise

Calories per Day

Oscai et al J Lipid Research 13:588-592, 1972.


Salans l b et al journal of clinical investigation 50 1005 1011 1971

OBESITY

Percent Fat (%)

Body Weight (g)


Salans l b et al journal of clinical investigation 50 1005 1011 1971

OBESITY

Fat Cell Number

Fat Cell Size


Salans l b et al journal of clinical investigation 50 1005 1011 1971

Changes in Lean & Fat Mass with Training - Men

Wilmore JH, Research Quarterly for Exercise and Sport 54:415-425, 1983.


Salans l b et al journal of clinical investigation 50 1005 1011 1971

Changes in Lean & Fat Mass with Training - Women

Wilmore JH, Research Quarterly for Exercise and Sport 54:415-425, 1983.


Salans l b et al journal of clinical investigation 50 1005 1011 1971

Total weight, fat mass & lean mass changes

with diet and exercise

Miller, WC et al International Journal of Obesity 21:941-947, 1997


Salans l b et al journal of clinical investigation 50 1005 1011 1971

Lean vs. Fat Mass Loss with Diet & Exercise

Fat

Weight Change (lbs)

Lean

Zuti & Golding, Physician & SportsMedicine 4:49-55, 1978


Salans l b et al journal of clinical investigation 50 1005 1011 1971

Lean vs. Fat Mass Loss In Overweight Adults

Lean

Fat

Weight Change (lbs)

Franklin, B., et al. Research Quarterly 1976.


Salans l b et al journal of clinical investigation 50 1005 1011 1971

SHORT vs. LONG BOUTS OF EXERICSE

Jakicic, et al. JAMA 282:1554-1560, 1999


Salans l b et al journal of clinical investigation 50 1005 1011 1971

ADHERENCE

Minutes per week

Jakicic, et al. JAMA 282:1554-1560, 1999


Salans l b et al journal of clinical investigation 50 1005 1011 1971

Weight Loss

Jakicic, et al. JAMA 282:1554-1560, 1999


Salans l b et al journal of clinical investigation 50 1005 1011 1971

Lifestyle Activity vs. Exercise is Weight Loss

Dunn, A.L. et al JAMA 281:327-334, 1999


Salans l b et al journal of clinical investigation 50 1005 1011 1971

MORBID OBESITY

Trend

No Wt Loss

Wt Loss

Reduce body fat in obese: Hill JO et al Physical Activity, Fitness, and Health: International Proceedings and Consensus statement, p 684-694, 1994.


Salans l b et al journal of clinical investigation 50 1005 1011 1971

PHYSICAL ACTIVITY & WEIGHT MAINTENANCE

Fogelholm, et al. Arch Int Medicine 160:2177-2184, 2000


Salans l b et al journal of clinical investigation 50 1005 1011 1971

N= 20 upper

N= 20 lower

  • UPPER:

  • Lost more on WHR

  • Lost only from Abd

  • Lost more weight

Walden et al, Am J Clin Nutr 47:229-234, 1988.

  • LOWER:

  • Lost Abd & Glut


Salans l b et al journal of clinical investigation 50 1005 1011 1971

OVEREATING STUDIES

(individual subjects)

Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.


Salans l b et al journal of clinical investigation 50 1005 1011 1971

EXERCISE & THE FAT CELL

Tremblay, A., Int J Obesity 8:641-648, 1984.


Salans l b et al journal of clinical investigation 50 1005 1011 1971

Fitness & Fatness

Lee, C.D., et al. American Journal of Clinical Nutrition 69:373-380, 1999


Salans l b et al journal of clinical investigation 50 1005 1011 1971

EXERCISE & NUTRITION

Percent Body Fat (%)

Pitts, et al Am J Physiol 246:R495, 1984


Salans l b et al journal of clinical investigation 50 1005 1011 1971

EXERCISE & METABOLIC RATE

Poehlman, E.T., Med Sci Sports Exerc 21:515-525, 1989


Salans l b et al journal of clinical investigation 50 1005 1011 1971

EXERCISE & FOOD INTAKE

Neiman, D.C., J A, Dietetic Assoc 90: 1557-1562, 1990


Salans l b et al journal of clinical investigation 50 1005 1011 1971

Postprandial Lipemia and Exercise

Aldred, H.E, et al Metabolism 43:836-841, 1994


Salans l b et al journal of clinical investigation 50 1005 1011 1971

*

*

*

*

*

*

Baseline

1 year

*


Salans l b et al journal of clinical investigation 50 1005 1011 1971

Baseline

1 year

*interaction


Salans l b et al journal of clinical investigation 50 1005 1011 1971

Baseline

1 year