Ch. 8 An Introduction to Metabolism. A organism’s metabolism is subject to thermodynamic laws. The totality of an organism’s chemical reactions is called metabolism .
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Through energy coupling, the exergonic process of ATP hydrolysis drives endergonic reactions by transfer of a phosphate group to specific reactants, forming a phosphorylated intermediate that is more reactive
The active site can lower the Eᴀ barrier by orienting substrates correctly, straining their bonds, providing a favorable microenvironment, or even covalently bonding with the substrate
Each enzyme has optimal temperature and pH. Inhibitors reduce enzyme function. A competitive inhibitor binds to the acive site, whereas a noncompetitive inhibitor binds to a different site on the enzyme