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The effect of pain-killers on quality of life in Osteoarthritis patients. Saeideh Dahaghin MD, PhD. Osteoarthritis A chronic disease of joints No cure available pain is the main symptom of osteoarthritis The most common reason of disability

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saeideh dahaghin md phd

The effect of pain-killers on quality of life in Osteoarthritis patients

Saeideh Dahaghin MD, PhD

slide2

Osteoarthritis

  • A chronic disease of joints
  • No cure available
  • pain is the main symptom of osteoarthritis
  • The most common reason of disability
  • To increase the quality of life in osteoarthritis pain-killers are the first choice
  • Surgery is the next available treatment
  • Generalised OA, pain-killers
slide3

Data on medication use in POHEM-OA

British Colombia Linked Health Data base (2003-2004)

probability of medication use in OA patient which was varied base on duration of OA and level of pain

Four type of pain-killers was used by OA patients;

Acetaminophen

NSAIDs

Coxibs

Opioid

POHEM-OA represent the side effects of pain-killers in five categories :

Gastro intestinal, Cardio vascular disease, Stroke, dyspepsia, other generic side effects

slide4

Health Related Quality of Life (HRQL)

  • Health utility index mark 3 (HUI 3) is an index of health related quality of life used in POHEM OA.
  • HUI is based on eight attributes:
  • Vision, hearing, speech, ambulation, dexterity, emotional function, cognitive function and pain.
slide6

Evaluated Scenarios

Base scenario

Extreme hypothetical scenarios

Scenario 0- no medication used by any OA patients

Scenario 1- all OA population used all possible medication (Acetaminophen, NSAIDs, Coxibs, Opioid).

Scenarios based on HUI level

1- 100% medication given to people with HUI 0.85 and lower, no medication to HUI above 0.85

2- 100% medication given to people with HUI 0.95 and lower, no medication to HUI above 0.95

Scenarios based on certain increase of basic medication use in OA patients

Base scenario : medication use according to data derived from

25%, 50%, 75% or 100% increase in base scenario of medication use

Scenario side effect 0 or side effect 10

slide12

The effect of pain-killers on HUI is different in older age

Older people after 60 years old suffers more often from side effects

We would like to study the balance of side effect and benefit on HUI in people older than 60 years old.

slide13

To study the effect of side effect in various age group we did not have pohem-OA ready

Change the parameter of the probability of getting side effect of medication for various age group

HUI and HALE for various age group

Behnam version of POHEM

.

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