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1. A. Meischer (1868) band rich in acid-phosphates

Molecular Biology. I . Introduction. A. History. 1. A. Meischer (1868) band rich in acid-phosphates. 2. F. Griffith (1928) protein not inherited molecule. 3. Luria, A. Hershey and M. Chase (1952) Viruses. Figure 10.1A. Figure 10.1C. 4. E. Chagraff (1952) T=A and G=C.

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1. A. Meischer (1868) band rich in acid-phosphates

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  1. Molecular Biology I. Introduction A. History 1. A. Meischer (1868) band rich in acid-phosphates 2. F. Griffith (1928) protein not inherited molecule

  2. 3. Luria, A. Hershey and M. Chase (1952) Viruses Figure 10.1A Figure 10.1C 4. E. Chagraff (1952) T=A and G=C

  3. 6. J. Watson & F. Crick (1953) built a model of DNA 5. R. Franklin (1952) uniform diameter, helical shape, highly repeatable Figure 10.3B Figure 10.3A

  4. II. DNA Replication A. Definition B. Rules 1. DNA Orientation  5’ to 3’ Figure 10.2A Figure 10.3D

  5. 2. Directional  Read 3’ to 5” lay down 5’ to 3’ Figure 10.4A 3. Semi-conservative Replication (Meselson & Stahl)

  6. C. Process by Players 1. DNA Helicase 2. RNA Primase Figure 10.5A

  7. 3. DNA Polymerase III 4.DNA Polymerase I

  8. 5. DNA Ligase

  9. D. Editing & Repair 1. Players and Process a. Editing = DNA polymerase I b. Repair = DNA nuclease, DNA polymerase, & DNA ligase

  10. E. Maintaining Length 1. Problem 2. Players a. Lengthen = DNA telomerase & DNA ligase

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