Brian Tenner CHEM 5398 22 April 2010. AntiFungals !. Early Beginnings – Difficulties Treating Common Fungal Infections Antifungal Drugs Newer Therapies Assigned Reading/References/Homework. Outline.
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
Keep in mind: We need to target differences between our cell and the fungal cell. Antibiotics will not work because of both cells are eukaryotic and the medication could kill off the good gut flora that competes with the fungus for nutrients. Treatments usually include many combinations of different antifungals.Common AntiFungals
Specifically inhibits the cytochrome P450 fungal enzyme C-14(alpha) demethylase. This enzyme is require in the 20 step pathway [thank goodness we didn’t have to memorize this] from lanosterol (intermediate in cholesterol synthesis) to ergosterol. Fluconazole binds to the Fe center of the enzyme (one of the nitrogens coordinates to the Fe).Fluconazole
Potent inhibitor of the fungal enzyme 1,3-(beta)-D glucan synthase. This enzyme catalyzes glucan polymerization (glucan is just a polymeric sugar molecule), which is essential in the synthesis of a fungi’s cell wall. Human cells do not possess a cell wall, so the drug is effective.caspofungin