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Investigation of Vaccinia Viral Protein Complex Role in Cell Entry Process

This study explores components of the vaccinia viral protein complex involved in virus entry. Glioma is a serious brain tumor derived from precursor glia cells. Research aims to induce glioma cell differentiation to reduce malignancy using Chinese herbal medicine. Traditional Chinese medicine attributes tumor formation to circulation blockage, proposing herbal drugs with "blood-activating and stasis-eliminating" properties as cancer therapy. Screening identified Sangjisheng, Cansha, Yusingcao, and Dewugong as potent differentiation-inducing agents for glioma cells.

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Investigation of Vaccinia Viral Protein Complex Role in Cell Entry Process

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  1. 牛痘病毒蛋白複合物在病毒進入細胞過程中扮演之角色Investigation of components of vaccinia viral protein complex involved in virus entry • Glioma is the most life threaten brain tumor. The glioma was pathologically degenerated from precursor glia cell. Some researcher proposed the ideal of induction glioma cell differentiation to astrocyte or oligodentrocyte such that decrease the degree of malignancy. Such differentiation inducing agents should be efficient therapeutic drugs with minor side effect on normal cells. My thesis work was aimed to explore potent glioma differentiation inducing agents in Chinese herbal medicine. In traditional Chinese medicine theory, the reason of tumor formation was due to circulation blockage of blood and body energy. Base on this theory, the putative efficient therapeutic Chinese herbal drugs for cancer therapy were those with “blood-activating and stasis-eliminating” actions. By using the C6 glioma as a target cell, we use 4mM sodium butyrate acting as positive control of cell differentiation-inducing and growth arresting agents to screen bioactive “blood-activating and stasis-eliminating” Chinese herbal drugs. In about fifty kinds of selected hearbal medicine, we have found Sangjisheng, Cansha, Yusingcao and Dewugong, showed potent differentiation inducing activity.

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