Coughing Linked With Advanced Lung-scarring Disease. Risk and unknown causes - PowerPoint PPT Presentation

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Coughing Linked With Advanced Lung-scarring Disease. Risk and unknown causes

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  1. Coughing Linked With Advanced Lung-scarring Disease. Risk and unknown causes studentdoctorprofessor.com.ua sdp.net.ua

  2. Cough can be 1)acute (<3 weeks)2) chronic (>8 weeks)Cough can be dry or wet.

  3. A cough in children may be either a normal physiological reflex or due to an underlying cause.In healthy children it may be normal in the absence of any disease to cough ten times a day.The most common cause of an acute cough is a viral respiratory tract infection.In adults with a chronic cough, i.e. a cough longer than 8 weeks, more than 90% of cases are due to post-nasal drip, asthma, eosinophilic bronchitis, and gastroesophageal reflux disease.The causes of chronic cough are similar in children with the addition of bacterial bronchitis.

  4. When idiopathic pulmonary fibrosis develops, tissue deep in the lungs becomes thick and scarred, likely due to a response to an unknown substance. The condition affects approximately 100000 individuals in the United States, and up to half die within three years of being diagnosed. 

  5. Almost all patients with idiopathic pulmonary fibrosis experience shortness of breath. The second most common symptom is cough. Shortness of breath is a known warning sign that a patient has a serious form of the disease, but little is known about the importance of cough.

  6. Cough was present in 84% of patients. It was more common in patients with advanced disease and in those who had never smoked. • Also, the presence of cough predicted more rapid disease progression, regardless of the severity of a patient's disease. The study's findings indicate that the presence of cough may predict which patients are likely to die prematurely or need a lung transplant in the near future.

  7. New research shows that idiopathic interstitial pneumonia (IIP), a group of potentially fatal disorders that affects the lungs, may be caused by an interaction between a specific genetic background and cigarette smoking. • IIPs are often accompanied by scarring and inflammation of the lung known as pulmonary fibrosis. Pulmonary fibrosis makes the delivery of oxygen to the body’s tissues difficult and is often fatal. About one-half of patients die within the first five years of being diagnosed with idiopathic pulmonary fibrosis. • New study illustrates the important role that a specific environmental exposure, in this case cigarette smoking, can play in the development of this type of lung disease among people who have a specific gene. It once again underscores why people should not smoke.

  8. Pulmonary fibrosis currently affects approximately 100,000 people in the United States, with an estimated 30,000 people being diagnosed each year. It could help lead us to strategies for genetic testing, prevention, and treatment of this devastating and complex disease. • If the families had 2 or more relatives with this disease, the researchers also found similar age-at-diagnosis and significant risk among siblings. Older people, males, and those who smoked also showed a greater risk of developing FIP. After controlling for age and gender, having ever smoked cigarettes increased the likelihood of developing this disease 3.6 times. • A certain genotype places someone at risk for this disease. Independent of genes, cigarette smoking also contributes to the development of this disease. The next step is to identify the specific gene or genes that cause the disease.

  9. Cough can be produced by excessive pharyngeal secretion, tonsillitis, non smoker or second hand smokers, where clinical sign absent completely.Radiographic view is normal.Sputum is normal.Blood test is normalLung congestion due to cardiac pathology is absent.Everything is perfect but patient is continue coughing, why?

  10. Reason may be any impairment of nervous system - damage of brain, which stimulate to access secretion of mucus without inflammation.All antitussive, mucolytic drugs are ineffective or have limited affection due to pathology of CNS.So, what should be our tactics; send to neurologist for nerve function test with CT or MRI scan to reveal brain pathology if present.

  11. Referenses1. http://www.nih.gov/news/pr/nov2005/nhlbi-01.htm2. http://www.medindia.net/news/Coughing-Linked-With-Advanced-Lung-scarring-Disease-Risk-92189-1.htm studentdoctorprofessor.com.ua sdp.net.ua