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Current Management of Esophageal Atresia and Tracheoesophageal Fistula

Current Management of Esophageal Atresia and Tracheoesophageal Fistula. George W. Holcomb, III, M.D., MBA Surgeon-in-Chief Children’s Mercy Hospital Kansas City, MO. Esophageal Atresia. EA/TEF. 1 per 2500 – 3500 live births Sporadic, non-syndromal Dysmotile distal esophagus

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Current Management of Esophageal Atresia and Tracheoesophageal Fistula

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  1. Current Management of Esophageal Atresia and Tracheoesophageal Fistula George W. Holcomb, III, M.D., MBA Surgeon-in-Chief Children’s Mercy Hospital Kansas City, MO

  2. Esophageal Atresia

  3. EA/TEF • 1 per 2500 – 3500 live births • Sporadic, non-syndromal • Dysmotile distal esophagus • Deficiency of tracheal cartilage • 50% have 1 or more associated anomalies: cardiac, anorectal, GU, vertebral/skeletal, others

  4. Postoperative Problems • GER: 40% (20% require fundoplication) • Mgmt: treat aggressively postoperatively ?partial vs complete fundoplication • Tracheomalacia: 10% symptomatic (<5% require aortopexy)

  5. EA/TEFPreoperative Evaluation • Echocardiogram – assess cardiac anomalies • Renal US – assess kidneys • CXR/spine films – assess vertebral anomalies • PE – assess limb, anorectal anomalies • US great vessels – assess location of aortic arch

  6. Thoracoscopic Repair EA/TEF Please use this link if you experience problems viewing the video above.

  7. American Surgical Association, 2005 Ann Surg 242:422-430, 2005

  8. Thoracoscopic Repair EA/TEF

  9. Thoracoscopic Repair EA/TEF • Retrospective study • Six international centers • 2000 – 2004 • 104 Pts

  10. Thoracoscopic Repair EA/TEF(104 Patients) • Tracheal intubation • 30 - 45º prone position • 3 ports (99 pts) • 4 ports (5 pts) • CO2 insufflation used

  11. Thoracoscopic Repair EA/TEF(104 Patients) • Fistula Ligation • 37 pts: suture ligation • 67 pts: clip ligation

  12. Thoracoscopic Repair EA/TEF (104 Patients) • Anastomosis – Suture • 46 pts: Vicryl • 40 pts: PDS • 11 pts: Silk • 7 pts: “Other” • Anastomosis – Technique • 42 pts: extracorporeal • 62 pts: intracorporeal

  13. Thoracoscopic Repair EA/TEFResults(104 Patients) Mean Age (days) 1.2 (± 1.1) Mean Wt (kg) 2.6 (± 0.5) Mean Operative Time (min) 129.9 (± 55.5) Mean Days Ventilation 3.6 (± 5.8) Mean Hospitalization (days) 18.1 (± 18.6)

  14. Thoracoscopic Repair EA/TEFAssociated Anomalies(104 Patients)

  15. Thoracoscopic Repair EA/TEFResults(104 Patients) • Fundoplication 26 (22 Nissen, 4 Thal) • Aortopexy 7 ( 6 thoracoscopic) • Duodenal atresia 4 (4 laparoscopic) • Imperforate anus 10 (7 high, 3 low) • Cardiac operations 5 ( other than VSD/ASD)

  16. Thoracoscopic Repair EA/TEFComplications(104 Patients) • Recurrent fistula 2 ( 3 mos, 8 mos) • Mortality 3 • 7 mo old - NEC • 10 day old – CHD • 21 day old with esophageal disruption at intubation

  17. Thoracoscopic Repair EA/TEFRight Aortic Arch6 Pts • Conversion from R thoracoscopy 3 to L thoracoscopy • Conversion from R thoracoscopy 1 to L open • Left thoracoscopy 2

  18. Thoracoscopic Repair EA/TEFStaged Operation • 1 pt: long gap – thoracoscopic ligation 3 mos later – repair via thoracotomy (2 myotomies needed)

  19. Thoracoscopic Repair EA/TEFConversion to Open5 Pts • 1 Pt: R aortic arch (despite negative ECHO) • 3 Pts: Intraoperative desaturation, relatively long gap • 1 Pt: 1.2 kg baby – only 1 port placed – too small

  20. Thoracoscopic Repair EA/TEF N.R.: Not reported A: 87% are Gross Type C B: Stricture is defined as a significant narrowing on the initial esophagram C: Stricture in this paper is defined as requiring > 4 dilations D: Stricture in this paper is defined as requiring > 2 dilations

  21. Preoperative Bronchoscopy Please use this link if you experience problems viewing the video above.

  22. Patient Position

  23. Port/Instrument Positions

  24. Impact Of Suture MaterialCMH • 99 patients • Absorbable suture used in 32 patients • Permanent suture in 62 patients • Combination used in 5 patients • No difference in weight at operation, EGA, age at repair, or mean number of associated anomalies between the groups. Ann PediatrSurg 3:78-82, 2007

  25. Impact Of Suture MaterialCMH Ann PediatrSurg 3:78-82, 2007

  26. Impact Of Suture MaterialCMH • There is no difference in leak rates based on suture material or size • Suture material or size has no effect on stricture formation Ann PediatrSurg 3:78-82, 2007

  27. EA/TEF Operative Approach ThoracoscopyThoracotomy

  28. EA/TEF Why Thoracoscopy? 89 pts/16 yrs • shoulder elevation: 24% • chest deformity: 20% • abduction limited: 100% • spine deformities: 18% • breast deformities: 27% (3/11) Jaureguizar E, et al: Morbid musculoskeletal sequelae of thoracotomy for tracheo-esophageal fistula. J PediatrSurg 20: 511-514, 1985

  29. Musculoskeletal Morbidity Following Thoracotomy for EA/TEF • Durning RP, et al: J Bone Joint Surg AM 62:1156, 1980 • Gilsanz V, et al: Am J Roentgenol 141:457, 1983 • Chetcuti P, et al: J Pediatr Surg 24: 244, 1989 • Goodman P, et al: J Comput Assist Tomogr 17:63, 1993 • Frola C, et al: Am J Roentgenol 164: 599, 1995 • Bianchi A, et al: J Pediatr Surg 33: 1798, 1998

  30. Thoracoscopic Repair EA/TEFAdvantages of Thoracoscopy • Avoidance of musculoskeletal sequelae • Superior visualization of anatomy • Easy to identify fistula for ligation

  31. Thoracoscopic Repair EA/TEFFistula Ligation • Metal clip • Weck clip • Tie (x2 ?) • Suture ligature (x2 ?) • Suture closure – tracheal side

  32. Second TE Fistula

  33. Tips/Tricks • Oscillating ventilator • U-clips anterior anastomosis Please use this link if you experience problems viewing the video above.

  34. 2007 – 2010 • 17 neonates • 12 EA/TEF • 5 CDH • Mean age - 4 days • Mean wt - 2.9 ±1.0 kg • Median vent changes – 3/pt J LaparoendoscSurg 21:877-879, 2011

  35. How To Get StartedNot The Ideal Case • 2 - 2.5 kg • Very high upper pouch • Complex single ventricle physiology • Prostaglandin dependent

  36. How To Get StartedIdeal Case • Baby – 2.5-3 kg; no other anomalies • Esophageal segments close together (CXR, Bronchoscopy) • Start thoracoscopically – Go as far as comfortable • Try it again

  37. Thoracoscopic Repair EA/TEFSummary • Thoracoscopic repair of EA/TEF can be performed safely and effectively • The thoracoscopic approach may be advantageous by reducing the musculoskeletal sequelae seen following thoracotomy

  38. QUESTIONS www.cmhmis.com

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