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Practical Implications of Sleep Neurochemistry . LASM November 2011 Kevin R. Hargrave, MD CNS Clinic, Lafayette LA . Practical Implications of Sleep Neurochemistry . Intro comments (3-15) Rx’s: top 5 in U.S. and most common of CNS clinic pt’s (16-27)

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practical implications of sleep neurochemistry

Practical Implications of Sleep Neurochemistry

LASM November 2011

Kevin R. Hargrave, MD

CNS Clinic, Lafayette LA

practical implications of sleep neurochemistry1
Practical Implications of Sleep Neurochemistry
  • Intro comments (3-15)
  • Rx’s: top 5 in U.S. and most common of CNS clinic pt’s (16-27)
  • Anatomy of sleep related neuronal centers/circuits (28-49)
    • Wake circuitry
    • Sleep NREM circuitry
    • REM circuitry
  • Brain Chemistry and sleep stages (49-89)
    • Wake neurochemicals
    • NREM neurochemicals
    • REM neurochemicals
  • Conditions (sleep d.o.’s) and tidbits thereof (90-105)
  • Drugs (effects on sleep) (106-130)
sleep
‘Sleep’

According to Dr. Dement,

Sleep: Two essential features

  • Perceptual wall bw conscious mind and outside world
  • Immediately reversible

And the brain “puts itself to sleep”

According to Freud, from his 1905 book Interpretation of Dreams, dreams represent

“the royal road to a knowledge of the part the unconscious plays in mental life”

practical implications of sleep neurochemistry2
Practical Implications of Sleep Neurochemistry

Anatomy (brain anatomy as it pertains to sleep)

Brain Chemistry (W, NR, R and their Nchem’s

Conditions (sleep d.o.’s)

Drugs(Rx’s and their effects on sleep)

sleep wake neuroanatomy
Sleep/Wake Neuroanatomy

http://courses.washington.edu

fly

Neurochemistry of Sleep and Wakefulness. Monti et al.

Genes Dev. 2010 Jun 15;24(12):1220-35.

slide9

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Tamakawa Y et al. J Neurophysiol 2006;95:2055-2069

©2006 by American Physiological Society

slide10

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Tamakawa Y et al. J Neurophysiol 2006;95:2055-2069

©2006 by American Physiological Society