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PMID:15889139. Mutations in two, or more, genes. IGI. Biological Process:. meiosis?. Mutations in a single gene. IMP. homologous recombination?. Physical interactions between proteins. IPI. with:. SGS1. TOP3. Cellular Component:. complex involving Sgs1p, Top3, and Rmi1p. IMP.

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Presentation Transcript
slide4
Mutations in two, or more, genes

IGI

Biological

Process:

meiosis?

Mutations in a single gene

IMP

homologous recombination?

slide5
Physical interactions between proteins

IPI

with:

SGS1

TOP3

Cellular Component:

complex involving Sgs1p, Top3, and Rmi1p

slide6
IMP

Biological

Process:

IGI

with:

S phase DNA damage checkpoint?

RAD53

MRC1

TOF1

CSM3

slide7
Biological Process:

increased recombination?

IMP

than wild type.

slide8
IMP

IGI

with:

SGS1

S phase DNA damage checkpoint?

Biological Process:

response to DNA damage?

slide10
Biological Process:

meiosis?

homologous recombination?

increased recombination?

S phase DNA damage checkpoint?

response to DNA damage?

Molecular Function:

Molecular function unknown

ND

no information

Cellular Component:

complex involving Sgs1p, Top3, and Rmi1p?

slide11
Cellular Component:

complex involving Sgs1p, Top3, and Rmi1p?

Searching/browsing for an

appropriate term did not identify

a term which described this

complex

snip

New Term?

Sgs1p/Top3 complex?

RecQ helicase-Topo III complex

slide13
Physical interactions between proteins

IPI

with:

SGS1

TOP3

Cellular Component:

complex involving Sgs1p, Top3, and Rmi1p

slide14
Cellular Component:

RecQ helicase-Topo III complex

IPI

with:

SGS1

TOP3

snip

slide15
Biological Process:

meiosis?

homologous recombination?

increased recombination?

S phase DNA damage checkpoint?

response to DNA damage?

slide18
Biological Process:

response to DNA damage stimulus

slide19
IMP

Biological

Process:

IGI

with:

response to DNA damage stimulus

RAD53

MRC1

TOF1

CSM3

slide20
2005-05-31

RAD53

CSM3

MRC1

TOF1

Inferred from Mutant Phenotype

SGS1

TOP3