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PARATRANSGENIC STRATEGIES FOR CONTROL OF VECTOR-BORNE DISEASES

AIMS. Provide overview of global impact of vector-borne diseasesProvide overview of Chagas diseaseDiscuss paratransgenic approach to Chagas diseaseProvide overview of visceral leishmaniasisDiscuss paratransgenic approach to visceral leishmaniasis in India . CONTROL OF VECTOR-BORNE DISEASES. Ve

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PARATRANSGENIC STRATEGIES FOR CONTROL OF VECTOR-BORNE DISEASES

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    1. PARATRANSGENIC STRATEGIES FOR CONTROL OF VECTOR-BORNE DISEASES Ravi V. Durvasula, M.D. Chief of Medicine, NM VA Health Care System Director, Center for Global Health, Dept of Internal Medicine UNM School of Medicine

    2. AIMS Provide overview of global impact of vector-borne diseases Provide overview of Chagas disease Discuss paratransgenic approach to Chagas disease Provide overview of visceral leishmaniasis Discuss paratransgenic approach to visceral leishmaniasis in India

    3. CONTROL OF VECTOR-BORNE DISEASES Vector-borne diseases remain a leading cause of human illness Over $60 billion loss annually to agriculture Impact on commercial livestock Lack of effective vaccines Vector eradication programs mainstay of control Pesticides effective over short term Issues of cost, environmental toxicity, adverse health effects and resistance

    5. Triatomine Vectors Reduviid bug aka “Kissing Bug”, “Assassin Bug” or La Chincha Multiple genera: Rhodnius, Triatoma, Panstrongylus Obligate blood-feeders Humans are innocent bystanders in the cycle

    6. Reduviid Bug Habitats Sylvatic and peri-domestic reservoirs Thatch roofing and cracks of adobe walls Up to 10,000 bugs per house Highly sequestered colonies

    7. Transmission of T. cruzi Nocturnal Kissing bug attracted to warmth and CO2 30 minutes to repletion Release of fecal/urine droplet at end of blood meal Droplet laden with metacyclic trypomastigotes Entry of parasites at site of wound or mucous membranes

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