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Advancements in Neuroimaging and Genetic Research: NA-MIC Contributions

This report highlights the developments in neuroimaging and genetic research within the NA-MIC framework. Key updates include the progress of the NA-MIC Kit, structural analysis advancements, and new methods for segmentation and shape analysis, especially in neuropsychiatric conditions like VCFS and NPSLE. Ongoing projects involve collaborations across leading universities, focusing on automated protocols, cortical thickness analysis, and longitudinal studies. The report emphasizes the need for strategic planning and advocacy for competitive renewal, ensuring continued funding and development in cutting-edge health research.

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Advancements in Neuroimaging and Genetic Research: NA-MIC Contributions

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  1. Introduction Ron Kikinis

  2. Logistics • Wireless Network available • Presenters: Please upload to the wiki • AHM: • Thursday morning: Present • Thursday afternoon: Future • Friday morning: EAB • Project week: Wednesday through Friday

  3. Bill@Murphy's Bar & Grill 160 South Main St. Phone: 801-359-7271 6:00pm-9:00pm: Thursday Evening

  4. Science • Year 3: organized around four themes • NA-MIC Kit • Structural Analysis • DTI • fMRI • Reports this morning

  5. NAMIC Kit Update • Slicer 3 • Significant progress • Modules now beingcontributed • Foundational Software • KWWidgets • CPack • DART, CMake • VTK, ITK • BIRN, InsightJournal

  6. Structural Analysis Update • New methods segmentation & shape leading to tools • Slicer integration • MGH Freesurfer • Coherent, joint effort across groups and cores for shape

  7. Expert Labels Clustered Data DWI/DTI Analysis • Algorithms • Low-level • Filtering and estimation • Segmentation • Higher-level • Tracts/paths • Altases • Software • Slicer/Slicer3 • Clinical results

  8. NA-MIC Structure

  9. Core 1: • Ross is Core 1 PI • Polina is now site-PI for MIT, Eric serves as senior advisor • Guido is moving to Utah

  10. Core 2: • Will replaces Bill as Core 2 PI, • Jim takes over the site PI function • Slicer3 beta is released

  11. Core 3: • Current DBP's • NA-MIC funding for current DBP’s ends 07-31-2007. • No follow-up grant applications until now!!! • New DBP's will use NA-MIC funding to transition into NA-MIC kit and develop application portfolio • Harvard • UNC • JHU/Queens • UNM

  12. Velo-Cardio-Facial Syndrome (VCFS) as a Genetic Model for Schizophrenia. PRINCIPAL INVESTIGATOR: Marek Kubicki, MD, PhD INVESTIGATORS: Martha Shenton, PhD Zora Kikinis, PhD Sylvain Bouix, PhD Marc Niethammer, PhD RESEARCH ASSISTANT: Doug Markant, BA BACKGROUND: • VCFS is a rare genetic syndrome (single copies of 30-45 genes on chromosome 22 are missing) • 30% of patients with VCFS develop schizophrenia AIMS: • To characterize anatomical similarities and dissimilarities between VCFS and Schizophrenia • To find “schizophrenia” genes DATA: • DTI, MRI, haplotypes, neuropsychology

  13. UNC Autism Study Longitudinal MRI study of early brain development in neuropsychiatric disorder: Heather Cody Hazlett, PhD (Co-PI Joseph Piven, MD) UNC Chapel Hill, Department of Psychiatry & the Neurodevelopmental Disorders Research Center • Possible projects for NA-MIC: • Substructure segmentation – automate existing protocols • (2) Cortical thickness – localized analysis, longitudinal • (3) DTI atlas – regional & localized analysis • (4) Shape analysis – automated, longitudinal Data: sMRI, DTI, behavioral /clinical Group age 2 age 4 Autism 56 28 DevDelay 10 6 TypDev 18 8

  14. JHU

  15. The MIND Institute / UNMThe Analysis of Brain Lesions in Neuropsychiatric Systemic Lupus Erythematosis INVESTIGATORS: H. Jeremy Bockholt Charles Gasparovic, Ph.D. CONSULTANTS: Vincent Magnotta, Ph.D. Vince Calhoun, Ph.D. Dominic Meier, Ph.D. PROGRAMMER: Sumner Williams, M.S. BACKGROUND: • NPSLE is an autoimmune disorder that causes neurological and psychiatric complications • Afflicted patients have distinct white matter lesions that vary over time • To understand the etiology of brain lesions in NPSLE, accurate measurement of lesion location, size, and time course must be achieved • AIMS: • Evaluate existing tools and develop new tools useing the NA-MIC kit for time series analysis of brain lesions found in NPSLE DATA: • MRI, DTI, perfusion, transcranial ultrasound, echocardiography, and neuropsychology Data collected under R01-NS35708-04

  16. Cores 4-7 • Web: move to new infrastructure • Training Core: Outreach events for 2007: Suggestions, Requests? • Leadership Core: • Steve Wong has moved to other activities. • Rachana Manandhar joins the administration team.

  17. Collaboration grants: • PAR's have been reissued. • NIH removed the restriction on prior collaborators. • Electronic submission required. • PAR-07-249 (R01)PAR-07-250 (R21) • Iowa funded to do FEM Mesh Generation • Several other applications are being submitted or are pending

  18. Strategic Planning • Competitive renewal is looming (if we are allowed to submit) • We need to identify NIH institutes who might co-sponsor NA-MICs competitive renewal: NIBIB, NLM, NCRR, NIMH, NCI….

  19. Define NA-MIC’s Strength • Mark Ellisman: What is our “Moonshot”? • We need a story that will be understood by people on the outside, including NIH and congress • Who are we relative to: • other software efforts such as SPM, Mathlab, FSL, LONI, Freesurfer, SCI, Paraview, BIRN etc. • other NCBC’s

  20. What is our offering? • Algorithm researchers: Toolkits and developers environment • Biomedical Engineers: we need scripting capabilities • Application scientists: we need turn-key solutions

  21. To-Do List for 2007 • Your NA-MIC funding is intended for NA-MIC relevant work • Use and improve the NA-MIC kit • Move to Slicer 3! • Cores 1 and 2 should work with the current DBP’s to exploit the NA-MIC kit: • Use-Scenarios • “Portable” Solutions • Collaboration Grants • Identify projects with the new DBP’s

  22. Project Week: June 25-29, MIT • Computer Scientists: Work on your source code using the NA-MIC kit • Produce Modules • DBP’s: Work on your data using the NA-MIC kit • Produce Procedure Manuals

  23. Enjoy !

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