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First workshop on pesticide analysis. Isabelle Windal & Vincent Hanot. Overview. CRL-NRL-official labs network CRL and NRL tasks Questionnaires Presentation of the discussion and conclusions of the CRL-NRL meeting in Germany in Decembre 2006 Freiburg Fellbach PT - summary.

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First workshop on pesticide analysis l.jpg

First workshop on pesticide analysis

Isabelle Windal & Vincent Hanot

1st Workshop on pesticide


Overview l.jpg
Overview

  • CRL-NRL-official labs network

  • CRL and NRL tasks

  • Questionnaires

  • Presentation of the discussion and conclusions of the CRL-NRL meeting in Germany in Decembre 2006

    • Freiburg

    • Fellbach

  • PT - summary

1st Workshop on pesticide


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CRL-NRL-official labs network

The European legislation describes a concept of a network of

  • Community Reference Laboratory (CRL)

  • And National Refernce Laboratory (NRL)

     to improve the overal quality, accuracy and comparability of the results at official control laboratories

1st Workshop on pesticide


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NRL

NRL

NRL

NRL

NRL

NRL

NRL

NRL

CRL

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NRL

NRL

NRL

NRL

NRL

NRL

NRL

NRL

CRL

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CRL

Cereals and

Feeding Stuff

(Copenhagen, Denmark)

CRL

Fruit and Vegetables

(Almeria, Spain)

Luis Martin-Plaza

CRL

Single Residue Methods

for Pesticide Residues

(Fellbach, Germany)

CRL

Food of Animal

and Commodities with

High Fat Content

(Freiburg, Germany)

1st Workshop on pesticide


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CRL

Cereals and

Feeding Stuff

(Copenhagen, Denmark)

CRL

Fruit and Vegetables

(Almeria, Spain)

Luis Martin-Plaza

CRL

Single Residue Methods

for Pesticide Residues

(Fellbach, Germany)

CRL

Food of Animal

and Commodities with

High Fat Content

(Freiburg, Germany)

1st Workshop on pesticide


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Information management

setup the network

develop websites and databases in order to

Create a Pool with analytically valuable information

Exploit synergy potentials in Information Management

Spend less time in retrieving information

Facilitate Decision-Making

Define Priorities

Allow grouping (profiling) and thus selection of Representative

Pesticides and Commodities based on sound information

CRL Tasks

1st Workshop on pesticide


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CRL Tasks (infomation: continued)

  • Pesticide Database:

    • Recovery data with different methods

    • Degradation behaviour of pesticides

    • Behaviour in Analysis (partitioning, cleanup)

  • Commodity Database:

    • Amount of co-extracted components

    • Behaviour in cleanup

    • Matrix Effects

  • Information about Laboratories:

    • Contact Information (contact persons…)

    • Instrumentation available

    • Specializations

    • Link to web-site & annual report

    • Expression of Interest to send or receive trainees

  • 1st Workshop on pesticide


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    www.Pesticides-online.com

    1st Workshop on pesticide


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    www.crl.cvuas.de

    1st Workshop on pesticide


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    CRL Tasks

    • Method development

    1st Workshop on pesticide


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    CRL Tasks

    • Interlaboratory method validation

      • On going: Acidic pesticides in cucumber, raisin, lemon, flour (15 labs) by the modified QUECHERS method or the ChemElute method

      • Future : Glyphosate in cereal

      • Future : Polar compounds in fruits and vegetables

    1st Workshop on pesticide


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    CRL Tasks

    • Organisation of proficiency tests

    1st Workshop on pesticide


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    CRL Tasks

    • Workshops and labs training

    1st Workshop on pesticide


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    CRL Tasks

    • Guideline drafting

    1st Workshop on pesticide


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    CRL Tasks

    • Providing scientific and technical assistance to the Commission, e.g. for the establishment of co-ordinated programmes

    1st Workshop on pesticide


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    Set priorities !!!

    1st Workshop on pesticide


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    NRL Tasks

    • Collaboration with CRL and official labs

    • Coordination of official labs activities

    • Organisation of ring test at the national level

    • Technical assistance

    1st Workshop on pesticide


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    Questionnaires

    • CRL Freiburg  NRL

    • CRL Fellbach  NRL & all official labs

    • NRL Belgium  you

       Only one time!! (Set up of the network!!!)

       Set priorities

       List of the labs to be invited for the intercomparison studies

    1st Workshop on pesticide


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    Please fill these questionnaires !!!!

    1st Workshop on pesticide


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    Meeting with CRL Freiburg (food of animal origin and comodities with high fat content)

    • Proficiency test 2006 for NRL: results

    • Proficiency test 2007 for all official labs

    • Main analytical and focus points and work programme

    • Quality management and validation

    1st Workshop on pesticide


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    1. Proficiency test 2006

    • To all NRL (20 labs)

    • Scope: organochlorines, pyrethroids and organophosphorous compounds in vegetable oil

    • Conclusions: labs need to

      • Improve the number of analyte followed (only 2 labs/20 able to analyse all compounds)

      • Decrease the spread of the results

    1st Workshop on pesticide


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    2. Proficiency test 2007

    • To all official labs (contribution of about 200 euros)

    • Scope: same than PT 2006: organochlorines, pyrethroids and organophosphorous compounds in vegetable oil (a list of 50 pesticides is provided from which10-15 pesticides are used to spike the oil)

    1st Workshop on pesticide


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    3. Main analytical and focus points and work programme

    • 3 groups of pesticides can be considered to be included in daily routine :

      • organochlorines,

      • pyrethroids and

      • organophosphorous

    • Other groups are extremely low covered

    • Need for exange of information about reason for the inclusion of certain groups in maximum levels for food of animal origin and in national residue control plan.

    1st Workshop on pesticide


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    4. Quality management and validation

    Two legislations:

    • Pesticides guidelines SANCO/10232/2006

      Pesticides in all food products

    • Commission decision 2002/657/EC Organic residues and contaminants in meat, fish, eggs, milk and honey

    1st Workshop on pesticide


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    SANCO > < 657/2002/EC

    1st Workshop on pesticide



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    What to do ????

    Favorite option

    separation of requirements for veterinary drug residue analysis (2002/657) and for analysis of pesticides and contaminants

    1st Workshop on pesticide


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    Chhhhuuuutttt…..

    • Separation between pesticides-contaminants and veterinary drug residues is proposed at this time via the revision of the directive 96/23/EC (NB: the 657/2002 implements the 96/23/EC)

      BUT

    • Possibly, the revision could enter into force in 2009 MUCH LATER than the entry into force of the 657/2002 (1st September 2007)

       In the meantime: we have to find another solution anyway

    1st Workshop on pesticide


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    1st Workshop on pesticide


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    Meeting with CRLs Fellbach validation of methods according to 2002/657 (so far 1

    Collaboration between with three CRLs: Fruit and Vegetables (Almeria, Spain), Cereals and Feeding Stuff (Copenhagen, Denmark), Single Residue Methods for Pesticide Residues (Fellbach, Germany)

    • Tasks of the CRLs

    • Scientific Presentation

    • Training

    1st Workshop on pesticide


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    1. Tasks : Fruit and Vegetables validation of methods according to 2002/657 (so far 1

    • Technical and Scientific Support to the Commission, EU Members State and Third Countries

    • Development and Validation of Analytical

      • Updating MRMs

      • New procedures

      • New MRMs

      • New procedures for extraction

    • EU AQC Guidelines

    • Proficiency Tests

    1st Workshop on pesticide


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    1. Tasks : Cereals and Feeding Stuff validation of methods according to 2002/657 (so far 1

    • Technical and Scientific Support to the Commission, EU Members State.

    • Interlaboratory method validation on glyphosate method

    • Collection and evaluation of information to support the prioritization of method development projects

    • Proficiency Test – PT C1

    1st Workshop on pesticide


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    1. Tasks - Single Residue Methods for Pesticide Residues validation of methods according to 2002/657 (so far 1

    • Technical and Scientific Support to the Commission, EU Members State

    • Method Development

      • Polar Compounds Quats, Glyphosate, certain metabolites

      • Dithiocarbamates

      • Volatile compounds Ethyleneoxide

      • Compounds amenable to Multiresidue Methods after modification

    1st Workshop on pesticide


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    1. Tasks - Single Residue Methods for Pesticide Residues /2 validation of methods according to 2002/657 (so far 1

    • Method Validation

      • Acidic Pesticides (already done)

      • Polar Compounds in Fruits and Vegetables

        Proficiency Test

    • Proficiency Test

      • PT SRM 1 (already done) (acidic, quats, organotin)

      • PT C1 -collaboration

    • Information Management

      • Pesticides on-line,…. (in collaboration with the other CRLs)

    1st Workshop on pesticide


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    2. Scientific Presentation validation of methods according to 2002/657 (so far 1

    Available on the web site

    • Pesticides on-line

    • Glyphosate method in HPLC-MS/MS (with membrane suppressor)

    • UPLC-MS/MS

    • TOF

      • GC-TOF and GCXGC TOF (In routine but LOQ,…)

      • LC-TOF (At this moment not in routine,…)

    1st Workshop on pesticide


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    3. Training validation of methods according to 2002/657 (so far 1

    • Lab presentation

    • Vendor Presentation

    • Quechers

      • Need to cryo-homogenisation

      • New version (other salts, pH,..)

    1st Workshop on pesticide


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    Profiency Tests - summary validation of methods according to 2002/657 (so far 1

    • 2006 - CRL

      • CRL Freiburg: OC, OP, Pyr in oil (NRLs)

      • PT-SRM 1 (acidic, quats, organotin in apple juice) (NRLs)

      • EU PT08 (All labs)

    • 2006 – NRL

      • OC in fat

    • 2007 - CRL

      • CRL Freiburg: OC, OP, Pyr in oil (all officials labs)

      • EU PT09 - Multi - F&V (all labs)

      • PT – CR1 Multi and single(NRL will communicate Official labs)

      • OC, OP, Pyr in oil (NRL have communicated official labs)

    • 2007 – NRL

      • OC in fat

      • Pesticides in F&V

    1st Workshop on pesticide


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    1 validation of methods according to 2002/657 (so far 1st Workshop on pesticide

    Questions, remarks,…

    Thank you for your attention

    1st Workshop on pesticide


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