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What is the Englis h Yew and how has it developed as an Effective Chemotherapy Agent?. By Amy Evans Economic Botany. Small to medium-sized evergreen tree Reddish-brown trunk with dark, flat leaves Every part of plant is poisonous due to Taxine. English Yew Taxus baccata l.

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what is the englis h yew and how has it developed as an effective chemotherapy agent

What is the English Yew and how has it developed as an Effective Chemotherapy Agent?

By Amy Evans

Economic Botany

english yew taxus baccata l

Small to medium-sized evergreen tree

  • Reddish-brown trunk with dark, flat leaves
  • Every part of plant is poisonous due to Taxine
English YewTaxusbaccata l.
slide3

Native to the pacific northwest

  • Extremely slow-growing
  • Can live for a very long time
  • One of the only conifers trimmed regularly into hedges
paclitaxel taxol
Paclitaxel(Taxol)
  • Monroe E. Wall and Mansukh C. Wani created the drug from the bark of the English Yew
  • Mitotic inhibitor
  • Used in breast, ovarian and lung cancer treatment
  • Given intravenously (IV)
  • Annual sales peaked in 2000, reaching $1.6 billion
side effects
Side Effects
  • Low blood counts
  • Hair loss
  • Joint and muscle pain (usually resolved within a few days)
  • Peripheral neuropathy
  • Nausea/ vomiting (usually mild)
  • Diarrhea
  • Mouth sores
  • Hypersensitivity

*all side effects experienced by more than 30% of the experimental group

studies
Studies
  • The first clinical report was issued in May of 1988 showing a 30% success rate in ovarian cancer patients
  • Paclitaxel Greenness Project by Bristol-Myers Squibb
  • Princeton- Ovarian Cancer
  • Vascular Research Center- Lung

cancer (preliminary)

  • Oxford Journal Study- Head/neck

cancer

references
References
  • http://www.britannica.com/EBchecked/topic/188318/English-yew
  • http://www.chemocare.com/bio/paclitaxel.asp
  • http://pubs.acs.org/cen/coverstory/8228/8228greenchemistry.html
  • Princeston Study
  • http://www2.prnewswire.com/cgi-bin/stories.pl?ACCT=104&STORY=/www/story/07-10-2000/0001261714&EDATE=
  • Vascular Research Center
  • http://www.vascularweb.org/professionals/Research/Basic_Articles/Neointimal_hyperplasia_clowes.html
  • Oxford Journal
  • http://jjco.oxfordjournals.org/cgi/content/full/34/9/499