Innovative Therapies for Lupus: Targeting the Innate Immune Pathway

Mar 01, 2025

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Explore cutting-edge treatments for systemic lupus erythematosus by focusing on the innate immune pathway. Learn about promising agents in development to revolutionize SLE management.

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Innovative Therapies for Lupus: Targeting the Innate Immune Pathway

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Table 1 Innate immune pathway-targeting agents in development for SLE Thanou, A. & Merrill, J. T. (2013) Treatment of systemic lupus erythematosus: new therapeutic avenues and blind alleys Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2013.145

Chapter 15: The Innate Immune Response

Chapter 15: The Innate Immune Response. Important Point:. If you are having trouble understanding lecture material: Try reading your text before attending lectures. And take the time to read it well!.

580 views • 25 slides

STEROID-SPARING ABILITY OF AGENTS IN SLE

STEROID-SPARING ABILITY OF AGENTS IN SLE. 9-30-03 FDA - 1.

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Overview : Innate Immune Response

Overview : Innate Immune Response. Inflammation. Recruitment from the bloodstream. Inflammation. Phagocytosis of a bacterium. Inflammation. Inflammation. Cells involved in innate i mmunity. • Neutrophils •Macrophages • Dendritic cells •Natural killer cells. Soluble Molecules.

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Psychologists Pathway for Development

Psychologists Pathway for Development. Submitted by Melodie Schaefer, Psy.D ., Chair, Division II (Education & Training) Board of the California Psychological Association; Board Member, California Psychological Association Chair California Psychology Internship Council (CAPIC).

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Signaling in the innate immune system PRR signaling

Manifestation of Novel Social Challenges of the European Union in the Teaching Material of Medical Biotechnology Master’s P rogrammes at the University of Pécs and at the University of Debrecen Identification number : TÁMOP-4.1.2-08/1/A-2009-0011.

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The Innate Immune Response

The Innate Immune Response. FUNCTIONS OF THE IMMUNE SYSTEM: Recognize , destroy and clear a diversity of pathogens. Initiate tissue and wound healing processes . Recognize and clear damaged self components. Exhibit “tolerance” to innocuous material including self.

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Receptors of the innate immune system

Receptors of the innate immune system. 06.04.2009 Nadine Sündermann. Receptors of innate immunity. are germline encoded consist of a ‘‘recognition’’ domain and a protein-protein-interacting region for downstream signaling act as a molecular switch to trigger innate immune activation

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Chapter 14: Innate Immune System

Chapter 14: Innate Immune System. Overview of Immune Defenses. First-line defenses: Intact, healthy skin and mucous membranes Normal microbiota. Overview of Immune Defenses. Sensory systems: Pattern recognition receptors Toll-like receptors NOD-like receptors RIG-like receptors

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Novel agents targeting the apoptosis pathway

Novel agents targeting the apoptosis pathway. Aaron D. Schimmer MD, PhD, FRCPC Princess Margaret Hospital Toronto, Canada. Cancer is an Elephant. Cancer is a defect In apoptosis. Therapy. Biology. Apoptosis. Survival. Survival. Survival. Survival. Death. Death. Death. Death.

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Overview : Innate Immune Response

Overview : Innate Immune Response. Inflammation. Recruitment from the bloodstream. Inflammation. Phagocytosis of a bacterium. Inflammation. Inflammation. Soluble Molecules. • Proinflammatory cytokines: •IL-1 • TNF a •Antimicrobial peptides

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Overview : Innate Immune Response

Overview : Innate Immune Response. Receptors Detect Infection. Toll-like Receptors. Toll-like Receptors. Signal Transduction. Signal Transduction. Ubiquity of Innate Immunity. Review: Cells of the Immune System. Leukocytes – White blood cells

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TARGETING THE CREB PATHWAY FOR MEMORY ENHANCERS

TARGETING THE CREB PATHWAY FOR MEMORY ENHANCERS. Tim Tully*, Rusiko Bourtchouladze*, Rod Scott* and John Tallman* Helicon Therapeutics and Cold Spring Harbor Laboratory. How are potential molecular targets for drugs found? How are potential memory drugs discovered and evaluated?

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Innate Immune System

Innate Immune System. IMMUNE SYSTEM FUNCTION To Protect against “entry” from microorganisms / pathogens - Bacteria - Viruses - Fungi - Parasites - Toxins - Venoms Recognize Pathogens Eliminate Pathogens

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Table 8.1 Innate cognitive drives

Table 8.1 Innate cognitive drives. Table 8.2 Drives versus motives. Table 8.3 ERG theory. Table 8.4 The motivation profile. Table 8.5 Strategies for reducing inequity. Table 8.6 Motivator and hygiene factors. Table 8.7 QWL versus HPWS.

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Innate Immune Response

Innate Immune Response. Jennifer Nyland, PhD Office: Bldg #1, Room B10 Phone: 733-1586 Email: jnyland@uscmed.sc.edu. Teaching objectives. Understand the mechanisms of combating infection/disease How does the body kill pathogens?

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Innate Immune Response (Ch14)

Innate Immune Response (Ch14). Overview of Innate Defense System. First lines of Defense. Physical Barriers Skin Mucous membranes Antimicrobial substances Lysozyme Peroxidase enzyme Lactoferrin Defensins Normal Flora. Epithelial Barriers. Skin as the first line of defense.

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Neutrophil – Innate Immune response

Neutrophil – Innate Immune response. Neutrophil. Know mediators that prime and stimulate the neutrophil function Know mediators secreted by the neutrophil Understand the role of anti-proteinases in neutrophil function Know immunomodulators of neutrophils function. Neutrophil. Neutrophil

992 views • 59 slides

Table 1 Possible molecular targets and corresponding biologic agents in SLE

Table 1 Possible molecular targets and corresponding biologic agents in SLE. Stohl, W. (2013) Future prospects in biologic therapy for systemic lupus erythematosus Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2013.136.

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Table 1 Kidney-specific intervention targeting CTGF

Table 1 Kidney-specific intervention targeting CTGF. Kok, H. M. et al. (2014) Targeting CTGF, EGF and PDGF pathways to prevent progression of kidney disease Nat. Rev. Nephrol. doi:10.1038/nrneph.2014.184.

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Receptors of the Innate Immune System

The ability to sense the presence of microorganisms that could cause potentially dangerous infections is a widespread property of cells, tissues and body fluids of all multicellular organisms. This process is called innate immune recognition.

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Innate Immune Response (Ch14)

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