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Mohammed Hammoudeh , M.D

Demographic and Clinical Characteristics of Rheumatoid Arthritis patients in some Arab States: Preliminary analysis . Mohammed Hammoudeh , M.D Division of Rheumatology, Department of Medicine, Hamad Medical Corporation, Doha, Qatar

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Mohammed Hammoudeh , M.D

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  1. Demographic and Clinical Characteristics of Rheumatoid Arthritis patients in some Arab States: Preliminary analysis Mohammed Hammoudeh,M.D Division of Rheumatology, Department of Medicine, Hamad Medical Corporation, Doha, Qatar Member of Middle East Rheumatoid Arthritis Consortium (MERAC) SaskiaMandey, Mohammed Hammoudeh, ZiyadMahfoud, Wessam G. Elhaq, Marjonneke J Mook-Kanamori, RawanShayboub, Samar Al Emadi, HumeiraBadsha, ImadUthman, Hussein Halabi, Basel Masri, LaylaKazkaz, Robert M. Plenge, Cindy McKeon,ThurayyaArayssi

  2. Disclaimer As faculty of Weill Cornell Medical College in Qatar we are committed to providing transparency for any and all external relationships prior to giving an academic presentation. Mohammed Hammoudeh M.D. I DO NOT have a financial interest in commercial products or service.

  3. RA in the Middle East Badsha H et al. Ann Rheum Dis 66, 835 (2007) Badsha H et al. ClinRheumatol 27, 739-42 (2008) • There are few systemic large studies of RA in the ME • 15 studies, largest 160 patients, single center • RA is more common in females • High proportion of RF positivity • Association with SE • Conflicting results of severity • Delay in initiation of therapy 1,2 • Low use of DMARDS 1,2 Current study: Genetic studies of Rheumatoid Arthritis in some Arab States (GRAAS)

  4. Genetic studies of Rheumatoid Arthritisin some Arab States Goal: • Investigate the genetic basis of RA in the Middle East by collecting at least 2000 RA controls and 2000 RA controls from 5 Rheumatology Centers across 5 Arab States. • Genome Wide Association Study (GWAS) that will test for >30 identified risk alleles identified in European and North American populations

  5. Objective of this Presentation Describe the demographic and clinical characteristics of the first 150 Rheumatoid Arthritis patients from 5 countries in the Middle East recruited to date

  6. Inclusion Criteria • Self reported Arab ancestry • Age > 18 • RA diagnosed per the ACR criteria • Ability to provide informed consent

  7. Data Collection • Two sets of data were collected: • Demographic and clinical data • Ancestry data, based on self-reported ancestry • All data entry is web-based and centralized at WCMC-Q

  8. Results

  9. Nationality percentage (%) Gulf Levant North Africa Analysis done on 150 patients in February 2013

  10. Demographics/ Clinical Analysis done on 150 patients in February 2013

  11. Clinical history Analysis done on 150 patients in February 2013

  12. Demographics Analysis done on 150 patients in February 2013

  13. Lifestyle Analysis done on 150 patients in February 2013

  14. Medications % (percentage) 86% of the patients are using Methotrexate; the use of biologics is low Analysis done on 150 patients in February 2013

  15. Conclusions The patient population of this study is relatively young in comparison to mean age (56.2 years) in the other large databases RF positivity and CCP positivity are low Large percentage of patients are illiterate, which may impact compliance and disease outcome Compared to the study done by Badsha et al, there is an increase in the use of Methotrexate (36% vs. 86%) but use of Biologics is still limited.

  16. Future Plans Analyze the demographic and clinical data on a regular basis Encourage more centers to join MERAC

  17. Acknowledgements King Faisal Specialist Hospital & Research center, Jeddah, Kingdom of Saudi Arabia Hussein Halabi Jordan Hospital, Amman, Jordan Basel Masri Tishreen Hospital, Damascus, Syria LaylaKazkaz Broad Institute, Cambridge, MA, USA Robert Plenge Weill Cornell Medical College-Qatar Saskia Mandey ZiyadMahfoud Wessam G. Elhaq MarjonnekeMook-Kanamori Cindy McKeon RawanShayboub ThurayyaArayssi Hamad Medical Corporation, Doha, Qatar SamarAl Emadi Al Biraa Arthritis and Bone Clinic, Dubai, UAE HumeirahBadsha American University of Beirut, Lebanon ImadUthman

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