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Bone marrow cells from PARP-1 KO mice display genomic instability following DNA damage

Bone marrow cells from PARP-1 KO mice display genomic instability following DNA damage. Sister Chromatid Exchanges (SCE). Chromatid / chromosomes breaks. 43.6. 4.3. 35.3. 2.7. 2.2. SCE. chromo. breaks. 17.1. 15.1. chroma. breaks. -/-. 9.7. -/-. +/+. .6. +/+. 3.4. .12. .08.

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Bone marrow cells from PARP-1 KO mice display genomic instability following DNA damage

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  1. Bone marrow cells from PARP-1 KO micedisplaygenomic instability following DNA damage Sister Chromatid Exchanges (SCE) Chromatid / chromosomes breaks 43.6 4.3 35.3 2.7 2.2 SCE chromo. breaks 17.1 15.1 chroma. breaks -/- 9.7 -/- +/+ .6 +/+ 3.4 .12 .08 control MNU 9h 2 Gy 7h control MNU 9h MNU 30h Ménissier- de Murcia J. et al. (1997) PNAS 94, 7303 - 7307

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