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Trifunctional Aminoamide Cellulose Derivative and its Characterization

This study explores the synthesis and characterization of a trifunctional aminoamide cellulose derivative, elucidating its structural properties and applications. It aims to utilize various techniques, including NMR, FT-IR, and GPC, to demonstrate the synthesis of a dendrimer-like material and confirm its structural integrity. The low intrinsic viscosity of the final product suggests potential suitability for drug delivery systems. Analysis of its molecular weight and conformation further enhances understanding for future applications in pharmaceutics and catalytic processes.

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Trifunctional Aminoamide Cellulose Derivative and its Characterization

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  1. Trifunctional Aminoamide Cellulose Derivative and its Characterization

  2. Outline • Objectives • Problem statement and motivation of the study • Presuppositions from Literature • Methodology

  3. Objectives • To illustrate how to use a couple of techniques to confirm the structural of a newly synthesized material and its intermediate. • To illustrate how to use a couple of techniques to characterize a final product and so provide some information for applications.

  4. Problem statement and motivation of the study • What are dendrimers? • “A dendrimer is a molecule with a form like the branches of a tree.”[1] • Dendrimers can be used in pharmaceutics, genetics, catalyst chemistry and superconductor currently or potentially. [2] [1] Wikipedia [2] Sand, Anders. Dendrimers and Their Technical Applicability

  5. Cellulose-based dendrimers Zhang, Changde et al. Biomacromolecules (2006), 7(1), 139-145.

  6.  Presuppositions from Literature • Narrow molecular weight distribution • The most exciting physical property of dendrimers is the variation of their intrinsic viscosities with molecular weight. [6] It is found that, when the generation increases beyond a certain point, the intrinsic viscosity begins to decline, contrary to the behavior of linear polymers (Fig.4). [6] http://www.dendritech.com/pamam.html

  7. Methodology • Using 1H to confirm the structural of intermediate product: • Using FT-IR to confirm and characterize the structural of CMCBA and CMCBADMPDA: • Using NMR to confirm and characterize the structural of CMCBA and CMCBADMPDA: • Using TGA to Characterize the Degree of Substitution of CMCBA and CMCBADMPDA: • Using Intrinsic Viscosity to characterize the conformation of CMCBADMPDA: • Using GPC-LS to characterize the MW and MWD of CMCBADMPDA:

  8. Using 1H to confirm the structural of intermediate product:

  9. Using FT-IR to confirm and characterize the structural

  10. Using NMR to confirm and characterize the structural of CMCBA and CMCBADMPDA:

  11. Using TGA to Characterize the Degree of Substitution

  12. Using Intrinsic Viscosity to characterize the conformation • CMC 5.62 dL/g, • CMCDMPDA 3.57 dL/g • CMCBADMPDA 0.39 dL/g

  13. Using GPC-LS to characterize the MW and MWD of CMCBADMPDA:

  14. Conclusions • The author got the “right ” product. • The product is of very low viscosity, which is suitable for drug delivery.

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