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MotifSpace --- one year review

MotifSpace --- one year review. Wei Wang Department of Computer Science University of North Carolina at Chapel Hill weiwang@cs.unc.edu. My Research. Data mining with bioinformatics applications MotifSpace: Graph-based Pattern Discovery in Protein Structures. Function.

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MotifSpace --- one year review

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  1. MotifSpace --- one year review Wei Wang Department of Computer Science University of North Carolina at Chapel Hill weiwang@cs.unc.edu

  2. My Research • Data mining with bioinformatics applications • MotifSpace: Graph-based Pattern Discovery in Protein Structures Function Functional motifs carry out protein function 3D structure of a protein

  3. G O C A T H S C O P MotifSpace Biological Experiments Protein Data Bank testable hypotheses Experimental validation protein structures protein family Pattern Filter Pattern Miner Protein Classifier Pattern Validation Subgraph mining Visualization Classification Feature selection structural patterns family-specific patterns Structural Pattern Database Functional Motifs Knowledgebase Indexing & Search Knowledge management Huan et al. ISMB’05 demo

  4. What MSNFF Enables • Increased external visibility • Important for junior faculty • Broader collaborations • Seed funds to initiate new collaborations • Crucial for interdisciplinary collaborations which are often if high risks and high returns

  5. As a Result … • Extending MotifSpace to study • RNA structures • Protein-protein and protein-ligand interactions • Chemical compounds • Broader collaborations • A systems biology approach to cardiovascular diseases • Complex trait analysis • In the future, • A center for bio-medical data mining

  6. © 2006 Microsoft Corporation. All rights reserved. Microsoft, Windows, Windows Vista and other product names are or may be registered trademarks and/or trademarks in the U.S. and/or other countries. The information herein is for informational purposes only and represents the current view of Microsoft Corporation as of the date of this presentation. Because Microsoft must respond to changing market conditions, it should not be interpreted to be a commitment on the part of Microsoft, and Microsoft cannot guarantee the accuracy of any information provided after the date of this presentation. MICROSOFT MAKES NO WARRANTIES, EXPRESS, IMPLIED OR STATUTORY, AS TO THE INFORMATION IN THIS PRESENTATION.

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