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MotifSpace --- one year review. Wei Wang Department of Computer Science University of North Carolina at Chapel Hill weiwang@cs.unc.edu. My Research. Data mining with bioinformatics applications MotifSpace: Graph-based Pattern Discovery in Protein Structures. Function.

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MotifSpace --- one year review


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motifspace one year review

MotifSpace --- one year review

Wei Wang

Department of Computer Science

University of North Carolina at Chapel Hill

weiwang@cs.unc.edu

my research
My Research
  • Data mining with bioinformatics applications
  • MotifSpace: Graph-based Pattern Discovery in Protein Structures

Function

Functional motifs carry out protein function

3D structure of a protein

motifspace

G

O

C

A

T

H

S

C

O

P

MotifSpace

Biological

Experiments

Protein

Data Bank

testable hypotheses

Experimental validation

protein

structures

protein family

Pattern

Filter

Pattern

Miner

Protein

Classifier

Pattern

Validation

Subgraph

mining

Visualization

Classification

Feature

selection

structural

patterns

family-specific

patterns

Structural Pattern

Database

Functional Motifs

Knowledgebase

Indexing &

Search

Knowledge

management

Huan et al. ISMB’05 demo

what msnff enables
What MSNFF Enables
  • Increased external visibility
    • Important for junior faculty
    • Broader collaborations
  • Seed funds to initiate new collaborations
    • Crucial for interdisciplinary collaborations which are often if high risks and high returns
as a result
As a Result …
  • Extending MotifSpace to study
    • RNA structures
    • Protein-protein and protein-ligand interactions
    • Chemical compounds
  • Broader collaborations
    • A systems biology approach to cardiovascular diseases
    • Complex trait analysis
  • In the future,
    • A center for bio-medical data mining
slide7

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