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1. Reference number Criteria forICH diagnosis Level of adjustment Adjusted OR (95%CI) Age DM Others AF HxStrk Sex NIHSS BP INR Case series Innsbruck NINDS  -  - - - -  - 13 NINDS    - -   - - 10 Modified SITS-MOST - - - - - - - - - 14 NINDS    -  - - - - 15 NINDS       -   16 N.R. - - - - - - - - - 17 Modified SITS-MOST - - - - - - - - - 11 N.R. - - - - - - - - - 12 ECASS - -   - -  -  Pooled estimate (random effects meta-analysis) 2.20 (0.99, 4.88) P=0.052 Pooled estimate (fixed effect meta-analysis) 1.90 (1.20, 3.01) P=0.006 I2 statistic (95%CI) 58% (11%, 80%) .01 .1 1 1 10 100 Figure e-2Adjusted random effects and fixed effect meta-analyses on the association between sub-therapeutic warfarin pre-treatment (INR≤1.7) and risk of intracranial bleedings. In four studies including 3451 patients intracranial bleedings were defined according to NINDS criteria, in one study according to ECASS III criteria (n=212), in two studies according to a modification of SITS-MOST criteria (parenchymal bleedings PH1 and PH2 with clinical deterioration ≥ 4 points on the NIHSS score) (n=391) and in two studies no information was reported on the diagnostic criteria used for the classification of bleedings (N.R.) (802 patients). Level of adjustment differs between studies and is detailed in the figure. If no adjusted ORs were presented in the publications unadjusted ORs were applied to allow comparison with the pooled estimates given in Figure 1. Abbreviations: AF, atrial fibrillation; BP, blood pressure; DM, diabetes mellitus; ECASS, The European Cooperative Acute Stroke Study; HxStrk, history of stroke; INR, international normalized ratio; NIHSS, National Institutes of Health Stroke scale; NINDS, National Institute of Neurological Disorders and Stroke; N.R., not reported; SITS-MOST, Safe Implementation of Thrombolysis in Stroke – Monitoring Study.