Publication bias in clinical trials. Kamran Abbasi Deputy editor, BMJ. Merhaba. I want to talk about . . . What is publication bias? Why does it matter? What is the evidence for it? What can be done about it? How has the BMJ responded?. There are many types of bias.
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Deputy editor, BMJ
(From Egger et al BMJ 2001;323:42-46 (7 July)
“Publication bias refers to the greater likelihood that studies with positive results will be published”
Publication bias is the selective or multiple publication or suppression of trial results so that the scientific record is distorted
(1.47 to 3.66)
(1.76 to 5.58)
Time to publication
4.7 vs 8.0 yrs
eg osteoarthiritis of the knee, multiple myeloma, psychiatric problems, Alzheimer’s disease, venous thromboembolism
eg tacrine, clozapine, 3rd generation OCP, erythropoietin, antidepressants, topical glucocorticoids, treatment for HIV