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(i) symmetric contacts (NOE) with Me-18,19. Chiral Solvation of BNDHP by Cholate Micelles. (i) A hydrophobic pocket is formed by facial methyl groups of an antiparallel dimeric unit of cholate, and Me-21 lies in the hydrophobic plane. Me 19. Me 18. Me 21. H5. H6. H4. H7. H3.

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(i) symmetric contacts (NOE) with Me-18,19

Chiral Solvation of BNDHP by Cholate Micelles

(i) A hydrophobic pocket is formed by facial methyl groups of an antiparallel dimeric unit of cholate, and Me-21 lies in the hydrophobic plane

Me19

Me18

Me21

H5

H6

H4

H7

H3

(ii) Enantiomers of BNDHP are preferentially solubilized against opposite edge of an antiparallel dimeric unit

H8

Me19

Me21

Me18

H4

H5

H3

H6,H8

H7

{Chol}Me18

Me19

Me18

H3

{Chol}Me19

H7

H8

H4

{Chol}Me21

H7

Me21

H5

H6

Cholate

R-BNDHP

(ii) inverted contacts (NOE) for edge groups

(ii)

H12

H4

H5

H3

H6,H8

H7

H7

{Chol}H7

{Chol}H12

H7

S-BNDHP

R-BNDHP

H12