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RADIOPHARMACOLOGY

RADIOPHARMACOLOGY. Radio. pharmaceutical. Ideal Radiopharmaceutical. Easily available. High Target vs. Non-Target ratio. . . . Particle Emission. Electron capture. Isomeric conversion. Decay Method. >30keV. <300keV. Short Effective half-life. l e = l p + l b.

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RADIOPHARMACOLOGY

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  1. RADIOPHARMACOLOGY

  2. Radio pharmaceutical

  3. Ideal Radiopharmaceutical Easily available High Target vs. Non-Target ratio    Particle Emission Electron capture Isomeric conversion Decay Method >30keV <300keV Short Effective half-life le = lp + lb b = 0.693 / Tb 1 = 1 + 1 . Te Tp Tb Tp x Tb Te = Tp + Tb

  4. Passive Diffusion DTPA - Brain imaging 133Xe

  5. Ion Exchange MDP

  6. Capillary Embolism MAA

  7. Phagocytosis Sulfur Colloid

  8. Active Transport 131I 201Tl

  9. Cell Sequestration Heat Damaged 99Tc-RBCs

  10. Metabolism 18F 18FDG

  11. Receptor Binding MIBG 11C Dopamine

  12. Compartmental Localization 99Tc – Ultratag / PYP

  13. Antigen – Antibody Complex Tumor Imaging Therapy

  14. Chemotaxis Tagged WBC

  15. Factors influencing design of new drugs

  16. Compatability

  17. Stoichiochemisrty

  18. Charge

  19. Size

  20. Protein Binding

  21. Solubility

  22. Stability

  23. Biodistribution

  24. Important factors in labeling Efficiency Stability Denaturation or Alteration Isotope Effect Carrier-Free or No-Carrier-Added (NCA) Storage and Shelf Life Specific Activity Radiolysis Purification and Analysis

  25. Adverse Effects Iatrogenic Alteration

  26. Anaphylactic Reaction HAMA Allergic Reaction MAA Sensitivity I-131

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