3.2 Review PBS. What is the DNA code? What is the connection between genes and proteins? . DNA is read in segments, called genes A gene is a particular sequence of nucleotide bases that code for a protein.
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Many amino acids have different properties (positive, negative, or neutral charge). Therefore the amino acids present and their order in the chain affect the shape of the protein due to the following forces:
Van der Waals forces – random attractive forces between atoms
Electrostatic charge – positive amino acids will attract negative amino acids and repel positive amino acids
S-S – Covalent bonds between amino acids with sulfur, these are stronger forces that hold the protein shape steady
Hydrogen bonds – bond formed between two molecules that are polar… (continues on next slide)
Page 1: Describe the 4 different types of proteins
Pages 2, 3, & 5: Be able to describe what happens with transcription & translation (using terms from pg. 5), and be able to walk through those processes. Also, describe what happens with protein synthesis with individuals with sickle cell anemia (what kind of mutation, and how does this work?)
Page 4: Compare/contrast sickle cell & Tay Sacs. Describe the 4 forces discussed on this page. Compare glutamic acid and valine. Include specifics like hydrophobic or hydrophilic, charge, and how they behave in water. This information should help you understand the difference in the shape of normal RBCs compared to sickle cells.