v i t il ig o n.
Skip this Video
Loading SlideShow in 5 Seconds..
V I T IL IG O PowerPoint Presentation
Download Presentation

Loading in 2 Seconds...

play fullscreen
1 / 11

V I T IL IG O - PowerPoint PPT Presentation

  • Uploaded on

V I T IL IG O. April 26th, 1999 Chemistry 412 Rick Helgemo. What is vitiligo?. Autoimmune disorder Genetic link Affects 1-2% of population Difficult to cure Harmful effects. “ Untreated” Vitiligo. Autoimmune disorder.

I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
Download Presentation

PowerPoint Slideshow about 'V I T IL IG O' - keahi

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.

- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
v i t il ig o


April 26th, 1999

Chemistry 412

Rick Helgemo

what is vitiligo
What is vitiligo?
  • Autoimmune disorder
  • Genetic link
  • Affects 1-2% of population
  • Difficult to cure
  • Harmful effects
autoimmune disorder
Autoimmune disorder
  • Melanocytes destroyed *Melanocyte-specific differentiation antigens *Tyrosinase, Dopachrome isomerase (TRP-2), gp100, MART-1
  • Immunoglobulin G recognizes TRP-2, causing immune response
  • Possible link to curing melanoma?
genetic links
Genetic Links
  • Two types-Segmental and nonsegmental
  • Polygenic nature, multifactorial inheritance
  • Autosomal and not linked to race or sex
  • Linked to other autoimmune diseases
  • Weakly heritable
curing vitiligo effects
Curing Vitiligo Effects
  • Long and difficult process, rarely 100% effective on individual
  • Always involves sunlight or ultraviolet light
  • Physical and chemical methods
  • Cosmetics
  • Depigmentation
  • Psychological counseling
chemical treatment options for vitiligo
Chemical Treatment Options for Vitiligo
  • Corticoids
  • Psoralens (PUVA)
  • Phenylalanine
  • P-aminobenzoic acid (PABA)
  • Cantharidin, a blister beetle secretion
physical treatment options for vitiligo
Physical Treatment Options for Vitiligo
  • Tattooing (micropigmentation)
  • Autologous skin grafts
  • Skin grafting using blisters
  • Autologous melanocyte transplantation
  • Combination of Sun and Sunscreen
  • “Anti-tyrosinase-related protein-2 immune response in vitiligo patients…;” Okamoto T, Irie RF, Fujii S, etal.; The Journal of Investigative Dermatology; Dec 1998; 111:1034-1039.
  • “Autoantibodies to Tyrosinase-related protein-1 detected in the sera… ;” Kemp EH, Waterman EA, Gawkrodger DJ, et al.; British Journal of Dermatology 1998; 139:798-805.
  • “A systematic review of autologous transplantation methods in vitiligo;” Njoo MD,Westerhof W, Bos JD, Bossuyt PMM; Archives of Dermatology, Dec 1998 134:1543-1549.
  • “The genetics of vitiligo in Korean patients;” Kim SM, Chung HS, Hann SK; International Journal of Dermatology 1998; 38:908-910.
  • “On the association between vitiligo and malignant melanoma;” Lindelof B, Hedblad MA, Sigurgeirsson B; Acta Dermatologica Venereologica; 1998 78:483-484.
  • “Tyrosinase as an autoantigen in patients with vitiligo;” Baharav E, Merimsky O, Shoenfeld Y, et al.; Clinical Experimental Immunology; 1996 105:84-88.
  • “Nonsurgical repigmentation therapies in vitiligo;” Njoo MD,Westerhof W, Bos JD, Bossuyt PMM; Archives of Dermatology; Dec 1998 134:1532-1540.
  • “Spontaneous repigmentation of vitiligo patches distant from the autologous skin…;” Malakar S, Dhar S; Dermatology; 1998 197:274.
more references
More References
  • “Treatment of vitiligo with oral and topical phenylalanine: 6 years of experience;” Camacho F, Mazuecos J; Archives of Dermatology; Feb 1999 135:216-217.
  • “UV-dependent melanocyte plasticity-The structure-function relationship;” Iyengar B; Indian Journal of Pathological Microbiology; 1996 39(2):105-109.
  • “Topical application of a melanotropin analogue to vulgar vitiligo dermo-epidermal minigrafts;” Schwartzmann-Solon AM, Visconti MA, Castrucci AML; Brazilian Journal of Medical and Biological Research; 1998 31:1557-1564.
  • “Repigmentation of vitiligo lesion after beetle dermatitis;” Parsad D, Saini R, Nagpal R; Dermatology; 1998 197:398.