1 / 23

CF week

This comprehensive overview delves into the anatomy and physiology of the respiratory system, focusing on the airway branchings from the trachea to the alveoli, pleural cavity, and lung structures. It examines normal ventilation processes, the mechanisms of diffusion, and the normal V/Q ratio, as well as the pathology of cystic fibrosis (CF). The course covers CF's inheritance, incidence, and various lung and pancreas complications, providing effective management options including physiotherapy and medications. Additionally, it highlights the psychosocial impact of living with CF.

kaveri
Download Presentation

CF week

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. CF week

  2. Anatomy of the LRT • Airway branchings & LMB vs RMB • Name levels from trachea to alveoli • Changes as we descend resp tract? • Pleural cavity • Lungs – lobes and fissures • Circulation • Innervation

  3. Respiratory epithelium

  4. Bronchus

  5. Bronchiole

  6. Terminal bronchiole

  7. Respiratory bronchiole

  8. Alveoli

  9. Physiology - mechanics • Pleural pressure • Muscles and movements in inspiration • Muscles and movements in expiration • Passive vs active expiration • Forces keeping alveoli open vs closed

  10. Physiology • Ventilation • Pulmonary ventilation vs alveolar • What causes dead space?

  11. Physiology • Diffusion • What are the layers of the blood-air-barrier? • What effects the rate of diffusion?

  12. Physiology • Perfusion • Normal V/Q ratio • Hypoxic pulmonary vasoconstriction

  13. Pathology of obstruction • Tubes – muscular vs non-muscular • Non-mechanical • Mechanical - extramural, intramural and intraluminal • Examples • Consequences

  14. CF • Type of inheritance? • Incidence

  15. Sequelae Lung • Abnormal mucous, less, thicker • Infection/ inflammation • Bronchiectasis Pancreas • Pancreatic obstruction leads to… Sweat gland • Decreased reabsorption of NaCl.

  16. Pancreatic pathology

  17. Sweat gland

  18. Other abnormalities • Bilateral absence of ductus deferens • Meconium ileus • Liver pathology • Males generally infertile, woman are not.

  19. Diagnosis • Sweat test and DNA test for CFTR mutation • 6 classes of mutation

  20. Management Can you list 5 management options?

  21. Management • Chest physiotherapy Postural drainage and manual techniques Breathing & airway clearance +/- PEP devices Exercise therapy • Medications Bronchodilators (preventers and relievers) Anti-inflammatory therapy Mucolytics & pulmozyme(rhDNase) • IV antibiotics (infective exacerbations) • Oxygen therapy (infective exacerbations, or end stage) • Nutritional support (+/- enzymes) • Transplantation (end stage) • Potential gene therapy - aim to restore CTFR function

  22. Psychosocial/burden of CF • Prognosis • Time consuming, life altering illness. • Costly • Good opportunity to learn about support and respite groups

  23. Surface anatomy 6,8 and 10 for lung. 8, 10 and 12 for pleurae.

More Related