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This document presents a detailed comparison between the proteases of HIV-1 and HTLV-1, focusing on their amino acid sequences, structural characteristics, and functional implications. Key sequences such as PQITLWQRPLVTIRIGGQLK for HIV-1 and PVIPLDPARRPVIKAQVDTQTSHPKTI for HTLV-1 are analyzed for similarities and differences. Insights into the His-tagged versions of HTLV-1 protease variants are also provided. The study highlights evolutionary aspects and potential avenues for therapeutic interventions targeting viral proteases.
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1 10 20 ↓ ↓ ↓ HIV-1 PR (wt) PQITLWQRPLVTIRIGGQLK HTLV-1 PR (wt)PVIPLDPARRPVIKAQVDTQTSHPKTI His-HTLV-1 125 PR MAHHHHHHGRP PVIPLDPARRPVIKAQVDTQTSHPKTI ↑ ↑ ↑ 1 10 20 30 40 50 ↓ ↓ ↓ HIV-1 PR (wt) EALLDTGADDTVLEEM S LPG R WKPKMIGGI HTLV-1 PR (wt)EALLDTGADMTVLPIALFSSNTPLKNTSVLGA His-HTLV-1 125 PREALLDTGADMTVI PIALFSSNTPLKNTSVLGA ↑ ↑ ↑ 30 40 50 60 70 ↓ ↓ HIV-1 PR (wt) G G F I K V R Q Y D Q I L I E I C G H K A I G T V L HTLV-1 PR (wt) G G Q TQDHFKLTSLPVLIRLPFRTTPIVLTSCL His-HTLV-1 125 PR G G Q TQDHFKLTSLPVLIRLPFRTTPIVLTSA L ↑ ↑ ↑ ↑ 60 70 80 90 80 90 ↓ ↓ HIV-1 PR (wt) V G P T P V N I I G R N L L T Q I G C T L N F HTLV-1 PR (wt)VDTKNNWAIIGRDALQQCQGVLYLPEAKGPPVIL His-HTLV-1 125 PRVDTKNNWAIIGRDALQQA QGVLYLPEAKGPPVIL ↑ ↑ ↑ 100 110 120
