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Botanical Research Centers: NIEHS Interests. Elizabeth A. Maull, Ph.D. Program Administrator, NIEHS. Historical. 1998 – National Toxicology Program held a Workshop on Herbal Medicines Recommendations More research on herbals

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botanical research centers niehs interests

Botanical Research Centers:NIEHS Interests

Elizabeth A. Maull, Ph.D.

Program Administrator, NIEHS

historical
Historical
  • 1998 – National Toxicology Program held a Workshop on Herbal Medicines
  • Recommendations
    • More research on herbals
    • A call for industry to identify and standardize product ingredients
    • Increase consumer education
national toxicology program efforts
National Toxicology Program Efforts
  • Herbs and active or toxic ingredients of herbs nominated and selected for study by NTP
  • Criteria – widespread human exposure
  • Assessments preformed by NTP
    • Acute high dose effects
    • Chronic low dose effects
    • Reproductive toxicity
    • Neurotoxicity
    • Immunotoxicity
national toxicology program efforts cont
National Toxicology Program Efforts (cont.)

Of special interest to the NTP:

  • Potential for herb/herb or herb/drug interactions
  • Responses of sensitive subpopulations
    • Pregnant women
    • Developing fetus
    • Young
    • Elderly
niehs focus for brc recompetition
NIEHS Focus for BRC Recompetition
  • Centers structured around a central scientific theme
  • Research projects that complement ongoing National Toxicology Program efforts
niehs focus for brc recompetition1
NIEHS Focus for BRC Recompetition

Agriculturally related issues

Biologically related issues

agriculturally related issues
Agriculturally Related Issues
  • Identification of environmental factors influencing the concentration of bioactive constituents
  • Localization of bioactive ingredients within the plant
  • Development of “fingerprinting” technologies
    • Identify the plant source of a botanical
    • Detection of adulterations of botanicals
biologically related issues
Biologically Related Issues
  • Mechanisms of action of bioactive ingredients
  • Identification of targets for botanicals (molecular, cellular, organ)
  • Identification of interactions (antagonistic or synergistic) with other botanical components
  • Potential botanical/botanical or botanical/drug interactions
biologically related issues cont
Biologically Related Issues (cont.)
  • Pharmacokinetic / pharmacodynamic analyses of botanicals
  • Study the role of botanicals as regulators of genetic pathways or epigenetic events
  • Identify and validate biomarkers of botanical intake or biological effects
botanicals of interest ntp http ntp server niehs nih gov htdocs liason factsheets herbmedfacts pdf
Aloe vera gel

Black cohosh

Bladderwrack

Blue green algae extract

Comfrey

Echinacea purpurea Ephedra

Ginkgo biloba extract

Ginseng and ginsenosides

Goldenseal

Green tea extract

Kava kava extract

Milk thistle extract

Pulegone

Senna

Thujone

Botanicals of Interest (NTP)http://ntp-server.niehs.nih.gov/htdocs/liason/factsheets/HerbMedFacts.pdf
slide11

Elizabeth A. Maull, Ph.D.

Program Administrator

Susceptibility and Population Health Branch

National Institute of Environmental Health Sciences

T: (919) 316-4668

F: (919) 316-4606

E: maull@niehs.nih.gov