JoVE – science video journal for biological and biomedical sciences

1. JoVE – science video journal for biological and biomedical sciences Moshe Pritsker, Ph.D. CEO, co-founder, JoVE

2. JoVE mission: increase productivity in biological and biomedical research JoVE approach: video-based scientific article

3. Why we need to publish research on video (and not only text) Real life Typical text article Position the metaphase spindle at 3 o’clock and hold it with holding pipette. Apply piezo pulses to penetrate the zonapellucida. Touch the metaphase plate with the enucleation pipette. Aspirate the spindle and withdraw the pipette. 1 picture is worth a 1,000 words

4. Text is not effective Text scientific literature does NOT provide an adequate description of experiments Non-efficient knowledge transfer in life sciences Much time and money spent on reproducing already published studies Low efficiency of research, education and drug discovery

5. Solution: Visualized Description of Experimental Methods Text doesn’t work? Show it in video!

6. Structure of scientific video-articles 1. Animated Abstract 2. Introduction of scientists 3. Experimental procedure 4. Discussion of results

7. New Article = Video + Text

8. Why scientists publish in JoVE • - Journal, Not Database • - Indexed in PubMed and Medline • Prestigous Editorial Board • - Make your research reproducible • - Show what you know to do to your colleagues • Spend less time on training • - Retain technology in your lab when experts leave

9. JoVE - Current Status • Published 44 montly issues, ~750 video-articles • 40 video-articles per month are produced in world leading universities • Areas covered: Neuroscience, Immunology, Developmental Biology, Cell Biology, Biochemistry, Bioengineering, Plant Biology, Psychology, Medicine and others • First-and-only video journal accepted for indexing in PubMed and Medline • - Most aerticles come from famous research universities in US and abroad: Harvard, MIT, Yale, NIH, Oxford, Cambridge, Max Planck, Weizmann Institute.... • Partnerships with traditional publishers: Science (AAAS), Current Protocols (Wiley), Springer Protocols (Springer) and Annual Reviews

10. Content from prestigious universities

11. Who publishes what in JoVE? • - Group of Eric Lander (MIT, Broad Institute) - genomics: • Hi-C: A Method to Study the Three-dimensional Architecture of Genomes • - Group of Rudolf Jaenisch (MIT) – stem cells: • Generating iPS Cells from MEFS through Forced Expression of Sox-2, Oct-4, c-Myc, and Klf4 • Group of Doug Melton (Harvard) – stem cells: • Derivation of Human Embryonic Stem Cells by Immunosurgery • Group of Arturo Alvarez-Buylla (UCSF) – neural development: • The Subventricular Zone En-face: Wholemount Staining and Ependymal Flow • Group of John Cooke (Stanford) – animal model of disease: • Murine Model of Hindlimb Ischemia • - Group of John Carlson (Yale) – behavior: • Proboscis Extension Response (PER) Assay in Drosophila

12. Usage – Web traffic 2007 2008 2009 2007 2008 2009 • 80,000 visitors per months • 210,000 downloads (3 pageloads per each visitor) • 20% return users

13. Testimonials Super idea. Excellent movie. Best wishes with your novel publishing concept. Thomas D. Pollard, PhD Professor, Yale University I just viewed an excellent little article on your site, and I would like to include it in the reference materials for my course. Moses Goddard, MD Associate Professor of Surgery, Brown University It is a great way of sharing the kinds of details that make all the difference but are very hard to put into a printed report. Helmut Hirsch, PhD, Distinguished Teaching Professor, University at Albany Thank you for creating and developing such an astounding resource for scientists! This is truly going to rapidly advance progress in all fields of research and the potential applications are endless. Lalitha Chandrasekher, Candidate for PhD Physiology and Biophysics, Georgetown Univ.

14. How it works: we film your video for you

15. Videographer Network to Produce Videos • Covers USA, UK, Canada, Germany, Netherlands, Austria, Switzerland, Sweden, Denmark, Israel, Japan and Australia • Cost-effective platform for large-scale production of scientific videos from all over the world. 40 videos produced per month.

16. Filming in University Labs I just wanted to say thank you for all of your professionalism and hard work with our team today. You and the team you assembled did a great job with the whole process (many faculty who saw us have commented positively)and you were able to still tolerate my less than stellar acting. Thanks again and I look forward to working with you all in the future. Glenn Glenn Raup PhD, RN, NE-BC Assistant Professor Harris College of Nursing & Health Sciences Texas Christian University

17. Institutions subscribed - 2010 • ~200 libraries subscribed: Harvard University, Massachusetts Institute of Technology – MIT, Brandeis University, Brown University, Cold Spring Harbor Laboratory – CSHL, Cornell University, Fred Hutchinson Cancer Research Center, George Mason University, Kent State University, Max-Planck-Institute for Medical Research (Germany), Mount Sinai School of Medicine – MSSM, National Institute of Health – NIH, National Taiwan University (Taiwan), Northeastern University of Illinois, Princeton University, Purdue University, Rockefeller University, Salk Institute, UC Davis, UC Irvine, UCLA, University of Verona (Italy), University of Hong Kong (Hong Kong), University of Iowa, University of Miami, University of New South Wales (Australia), University of Southern California – USC, University of Waterloo (Canada), University of Zurich (Switzerland), Vanderbilt University, Weizmann Institute of Science (Israel), Wellesley College, Yale University, Yonsei University (Korea),…

18. JoVE sister journals In 2010: JoVE: www.jove.com JoVE Neuroscience: www.jove.com/neuro JoVE Immunology: www.jove.com/ii …. Plan for 2011: JoVE Oncology JoVE Bioengineering

19. What kind of journal do you want?

20. JoVE Team

21. Testimonial I recently had the opportunity to publish in the Journal of Visualized Experiments (JoVE), the online video journal for biological sciences.  I came across JOVE when I was trying to understand the methodology of chromatin immunopreciptation assays.  The text is accompanied by video demonstrations which makes the methodology of the experiments much more clear. Thus, JOVE  is a very  unique and useful resource for researchers, graduate students, postdocs and undergraduates in science.  This novel visualization approach will improve reproducibility of experimental studies, and increase the efficiency of research and education in the biological sciences. Dr. John Cooke Professor of Medicine, Associate Director, Stanford Cardiovascular Institute.