Clinical Appraisal of an Article on Prognosis. The Clinical Question. What is the risk of mortality among patients with hyperuricemia who received allupurinol ? PUBMED Search/Mesh Terms : Allopurinol Hyperuricemia Mortality Survival Advanced Search: Humans Males English.
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What is the risk of mortality among patients with hyperuricemia who received allupurinol?
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Allopurinol and mortality in hyperuricaemic patients
Andrew J. Luk1, Gregory P. Levin2, Elya E. Moore3, Xiao-Hua Zhou1, Bryan R. Kestenbaum4 and
Hyon K. Choi
Is the objective of the article on prognosis similar to your clinical dilemma?
Yes. The study aims to:
Was there a representative sample of patients without the outcome at the start of observation?
Yes. VA Consumer Health Information and Performance Sets (CHIPS) database was used:
Where the criteria for determining the prognostic factor and outcome explicit and credible?
Was follow-up siufficiently long and complete?
Was there adjustment for other prognostic factors?
Since all the validity questions were fulfilled, the study can be considered to be valid.
How large is the likelihood of outcome to occur in those with the prognostic factor in a specified period of time? Was it statistically significant?
Were the study patients similar to my own ?
Are results useful for reassuring or counseling patients?