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Nutritional Disorders. Dr. Shreedhar Paudel 04/02/ 2009. Malnutrition. One of the major causes of death in children < 5 yrs of age Infants ( up to 1 yr of age) on an average require 103 kcal/kg/day

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nutritional disorders

Nutritional Disorders

Dr. Shreedhar Paudel

04/02/ 2009

malnutrition
Malnutrition
  • One of the major causes of death in children < 5 yrs of age
  • Infants ( up to 1 yr of age) on an average require 103 kcal/kg/day
  • Even in children who die of pneumonia, diarrhoea, measles– malnutrition is a significant underlying factor
protein energy malnutrition
Protein-Energy malnutrition
  • One of the most serious health problem of children of developing countries
  • WHO definition– “PEM is a range of pathological condition arising out of coincident lack of protein and energy in varying proportions, most frequently seen in infants and young children and usually associated with infections”
protein energy malnutrition4
Protein-Energy malnutrition….
  • Risk factors:-
    • Age—6 mo to 18 mo; child is growing fast, food commonly given is not adequate
    • Sex—many cultures boys valued more than girls → girls neglected
    • Many children
    • Short interval between births
protein energy malnutrition5
Protein-Energy malnutrition….
  • Risk factors:-
    • Failure or stoppage of breast feeding
    • Delay in introducing additional food
    • Infectious diseases, especially—repeated diarrhoea, whooping cough or measles
    • Low birth weight
    • twins
protein energy malnutrition6
Protein-Energy malnutrition….
  • Diagnosing Tools?
    • WEIGHT for age
    • HEIGHT for age
    • ARM Circumference
    • CRANIAL Circumference
marasmus contd
Marasmus contd….
  • one component of protein-energy malnutrition (PEM)
  • severe form caused by inadequate intake of protein and calories, and it usually occurs in the first year of life, resulting in wasting and growth retardation, no edema
marasmus contd14
Marasmus contd….
  • Results from a negative energy balance

--decreased energy intake

--increased energy expenditure, or

--both,

( such as that observed in acute or chronic disease)

  • Occurs in infants exclusively on mother’s milk when the amount of breast milk is markedly reduced; inadequately prepared bottle milk
marasmus contd15
Marasmus contd….
  • Children adapt to an energy deficit with

--decrease in physical activity

--lethargy

--decrease in basal energy metabolism

--slowing of growth

--finally weight loss

marasmus contd16
Marasmus contd….
  • Clinical features:
    • Skin is thin, flaccid, wrinkled, seeming larger than the body it covers
    • Bony prominences protrude due to loss of subcutaneous fat
    • Drastic loss of adipose tissue from normal areas of fat deposits like buttocks and thighs ( buccal pad of fat is preserved till the malnutrition becomes extreme)
marasmus contd17
Marasmus contd….
  • Clinical features:-
    • Abdomen is distended due to wasting and hypotonia of abdominal wall muscle
    • irritable and may show voracious appetite
    • alternate bands of pigmented and depigmented hair (flag sign)
    • flaky paint appearance of skin due to peeling
hafiz usman warraich roll 17 c kwashiorker
HAFIZ USMAN WARRAICH ROLL #17-C Kwashiorker
  • Condition arises when a child recieves a diet very low in proteins but adequate calorie to satisfy the child’s need
  • Occurs weeks or months after weaning if weaning food is deficient in protein (human milk had sufficient protein till that time)
kwashiorker
Kwashiorker……
  • Clinical features:-
    • Markedly retarded growth
    • Psychomotor changes
    • Edema – of dependent parts
    • Mental changes
      • Lethargic, listless, apathetic
      • Little interest in environment—does not play
      • Rejects examination by physician
      • Appetite—impaired and difficult to feed him orally
kwashiorker20
Kwashiorker……
  • Edema caused by—
    • Hypoalbuminemia
    • Increased capillary permeability as a result of infection
    • Free radical induced damage to cell membrane
    • Fat, chubby appearance with moon shaped and puffy face (contrary to marasmus)
kwashiorker21
Kwashiorker……
  • Dermatosis

--large areas of erythema simulating second degree burns

-- progressively dry, hyperkeratotic and hyperpigmented

  • Hair—dry, thin, looses its normal color and lusture and easily pulled out
kwashiorker22
Kwashiorker……
  • History of diarrhoea almost always present
  • Fatty changes in the liver ( hepatomegaly)
  • Atrophy of intestinal mucosa
  • Atrophy of acini in pancreas
  • HAFIZ USMAN WARRAICH ROLL #17-C
management of pem
Management of PEM
  • Grade the nutritional status of the child
  • Find out the probable cause for malnutrition
  • Mild malnutrition:- nutritional advice for proper feeding and treatment of underlying conditions responsible for poor feeding (e’g: worm infestation, skin infections, nutritional anaemia)
management of pem24
Management of PEM……..
  • Moderate malnutrition:-

--will respond to nutrition education and demonstration in absence of any disease and adequate appetite

--treatment of underlying condition

--difficult cases with severe refusal of food—admission in hospital required

management of pem25
Management of PEM……..
  • Criteria for admission:-
  • Weight less than 60 % with
    • Edema
    • Severe dehydration
    • Diarrhoea
    • Hypothermia
    • Shock
    • Systemic infection; jaundice; bleeding
    • Age less than 1 year
    • Persistent loss of appetite
management of pem26
Management of PEM……..

Follow up Discharge Prevent

Catch up Relapse

growth & Restore Wt for Ht

Rehabilitaion

Initiation Begin feeding , Energy defense

of feeding feeding , Stimulation, Transfer to home

Treatment of Sugar deficiency, Hypothermia, Infection,

Complications Electrolyte imbalance, Dehydration, Deficiency of micronutrients

management of pem27
Management of PEM……..
  • Treatment of complications:- (Day 1-2)
    • S- sugar deficiency i.e., hypoglycemia
    • H- Hypothermia
    • I- Infection and septic shock
    • EL- Electrolyte imbalance
    • DE- Dehydration
    • D- deficiencies of iron vitamins & other micronutrients
    • HAFIZ USMAN WARRAICH ROLL #17-C
management of pem28
Management of PEM……..
  • Hypoglycemia:-

--May present with seizures or loss of consciousness

--Treated with IV infusion of glucose solution

  • Hypothermia:-

--children < 1 yr of age, with marasmus, extensive skin loss or serious infections

--cover with blanket & monitor patient

management of pem29
Management of PEM……..
  • Infections:-

--treat accordingly

  • Septic shock:-

--it’s very difficult to differentiate severe dehydration and septic shock

--all such children are treated with IV fluids for 1st two hours as for severe dehydration

--in case child doesn’t improve after 2 hrs of intensive fluid replacement—Septic shock strongly considered

--Broad spectrum antibiotics started ASAP

management of pem30
Management of PEM……..
  • Dehydration:-

--evaluation of dehydration is difficult

--loss of elasticity of skin can be due to loss of subcutaneous fat or dehydration

--dehydration– oral mucosa feels dry, no tear secretion when child cries, decreased formation of urine

management of pem31
Management of PEM……..
  • Dehydration mgt:-

--IV therapy for severe dehydration and shock

RL or N/2 saline in 5 % dextrose

(30ml/kg in 2 hours)

N/6 saline in 5% dextrose

(100ml/kg at the rate of 10ml/kg/hr in next 10 hrs)

same solution at half the rate( 5ml/kg/hr)

(next 12hrs)

management of pem32
Management of PEM……..
  • Dehydration mgt:-

once dehydration is corrected

maintenance fluid

(N/6 in 5 % dextrose at the rate of 75- 100ml/kg/day till feeding is established)

management of pem33
Management of PEM……..
  • ReSoMal (rehydration solution for severely malnourished child → supplements more of potassium

-- undernourished and dehydrated children are deficient in potassium and have relatively higher sodium levels

--can be prepared by mixing 1 pkt of ORS in 2 lts of water + 50 gm of sucrose + 40 ml of mineral mix solution( with high potassium)

management of pem34
Management of PEM……..
  • Electrolyte imbalance:-

--sodium intake restricted to prevent sodium overload and water retention

--severely malnourished children with superimposed diarrhoea or infection may develop severe hypokalemia → so requires extra supplement of potassium

management of pem35
Management of PEM……..
  • Congestive heart failure:-

--may occur secondary to

-overhydration

-severe anaemia

-high sodium intake

--diuretics should never be given to reduce edema in malnourished patients

--digoxin is used only when there is ↑JVP and potassium level is normal

management of pem36
Management of PEM……..
  • Associated nutritional deficiency:-

--severe anaemia– requires treatment

--vitamin A deficiency– needs supplement

--Vitamin k—single dose 2.5 mg im

--magnesium sulfate– 2 ml of 50% soln on day 1 of therapy

--folic acid—5mg on 1st day followed by 1mg/day

management of pem37
Management of PEM……..
  • Dietary Therapy:- (Day 3-7)
    • B- Beginning of feeding
    • E- Energy dense feeding
    • S- Stimulation of emotional and sensorial development
    • T- Transfer to home –based diets before discharge or transfer to nutritional rehabilitation centers
dietary therapy
Dietary therapy..
  • Start with lower volume of feed and increase gradually
  • Milk based diets are the most suitable initially
  • Start with energy of 80KCal/kg/d and protein 0.7g/kg/d
  • Gradually increase to energy of 150 Kcal/kg/d and protein 2-3 g/kg/d in a week
  • Fluid should be limited to 100-125 ml/kg/d
  • After 1 wk you can start energy dense feeding
management of pem39
Management of PEM……..
  • Recovery and Discharge:-

--Early signs of recovery

-return of appetite

-gain in body weight with loss of edema

-disappearance of hepatomegaly

- rising serum albumin

management of pem40
Management of PEM……..
  • Criteria for Discharge:-

--appetite returned, adequate oral intake

--constantly gaining weight at normal rate

--all infections, vitamin and mineral deficiencies been treated

--immunization initiated

--mother educated about home care

management of pem41
Management of PEM……..
  • Follow Up:-

--To prevent relapse

--To assure continued physical, mental and emotional development

--Reviewed periodically; after

-1 week

-2 weeks

-1 month

-3 months

-6 months after discharge